With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129799-15-1,Methyl 1-Boc-piperazine-2-carboxylate,as a common compound, the synthetic route is as follows.
The compound (S) -5- (1 – ((tert-butoxycarbonyl) amino) ethyl) -2- (3- (cyclopropylmethoxy) -4-(difluoromethoxy) phenyl ) -oxazole-4-carboxylic Acid (0.25g, 0.53mmol), 1-Boc-2- piperazine carboxylate(157mg, 0.64mmol), 1- ethyl-3- (3-dimethylaminopropyl) carbodiimide Hydrochloride (153mg, 0.80mmol)and N- hydroxy-7-aza-benzotriazole (181mg, 1.33mmol) was dissolved in dichloromethane (20mL) Theconditions at 0 C to this solution was added dropwise N, N- diisopropylethylamine (0.37mL, 2.13mmol), 5Hstirred at room temperature, the solvent was removed, Concentrate was separated by column chromatography(eluent: Petroleumether / EtOAc (v / v) = 3/1), to give 260mg colorless viscous substance, yield: 70.
129799-15-1, The synthetic route of 129799-15-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
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