With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.,13889-98-0
A solution of the compound of formula 15 (9.0 g, 52.6 mmol) was added to the reaction flask at room temperature,30 mL of N, N-dimethylacetamide,The compound of formula 16 (7.4 g, 57.8 mmol)N, N-diisopropylethylamine (8.1 g, 63.1 mmol)90 reaction 5 ~ 6h,TLC monitoring reaction is complete,The reaction solution was poured into 200 mL of water,Extracted with ethyl acetate (60 mL x 3)Combined organic layer,Washed with saturated brine,Dried over anhydrous sodium sulfate,The compound of formula 17 (12.71 g) was obtained by steaming,As a yellow solid (yield 86.4%).
13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Zhang Yinsheng; Gao Yong; Ren Jing; Wang Qinglin; Wang Zhao; (67 pag.)CN106905245; (2017); A;,
Piperazine – Wikipedia
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