4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4318-42-7
Step B/lntermediate B94: 1-[2-fluoro-3-(methyloxy)-4-nitrophenyl]-4-(1- methylethyl)piperazine; A pressure flask was charged with 1 ,2-difluoro-3-(methyloxy)-4-nitrobenzene (3.5 g, 18.5 mmol), dimethylsulfoxide (100 ml_), isopropyl piperazine (5.41 ml_, 22.2 mmol) and potassium carbonate (5.1g, 37.04 mmol). The resulting slurry was warmed to 7O0C and stirred overnight. The next morning, the orange solution was poured into water and extracted with diethyl ether. The organic layer was dried over sodium suflate, taken to a residue under reduced pressure, and purified via chromatography on SiO2 (0 to 10percent MeOH/CH2CL2 with 0.2percent NH3) to afford 1-[2-fluoro-3-(methyloxy)- 4-nitrophenyl]-4-(1-methylethyl)piperazine as a yellow solid (5.7g, quant, yield). 1 H NMR (400 MHz, CDCI3) delta ppm 1.10 (d, J=6.60 Hz, 6 H), 2.71 (s, 4 H), 2.76 (s, 1 H), 3.29 (s, 4 H), 4.03 (s, 3 H), 6.64 (dd, J=9.53, 8.07 Hz, 1 H), 7.70 (dd, J=9.35, 2.02 Hz, 1 H).
The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/20990; (2009); A1;,
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