With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: 2,6-Dichloro-9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-9H-purine (24) (447 mg, 1 mmol) was dissolved in 5 mL absolute EtOH, then 1-(alpha,alpha,alpha-trifluoro-p-tolyl)piperazine (0.23g, 1 mmol)/ 2-(1-cyclohexenyl) ethylamine (0.125g, 1 mmol) and (Et)3N (3 equiv) were added. The mixture was refluxed for 10-12 h. The reaction mixture was concentrated in vacuo and the residue was purified by column chromatography. 2-Chloro-6-[4-(4-trifluoromethylphenyl)piperazine-1-yl]-9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-9H-purine (25) The compound was prepared from (24) and 1-(4-trifluoromethylphenyl)piperazine according to the general procedure and was purified by column chromatography (EtOAc-hexane, 1:2) to yield 25 as viscous oil (850 mg; 75%). 1H NMR (CDCl3) delta 2.0 (s, 3H, CH3), 2.02 (s, 3H, CH3), 2.09 (s, 3H, CH3), 3.44 (br s, 4H, piperazine CH2), 3.94-4.72 (m, 7H, H-4?, CH2-5?, piperazine CH2), 5.55 (t, 1H, H-3?), 5.86 (t, 1H, H-2?), 6.16 (d, 1H, H-1?), 7.09 (d, J = 8.8 Hz, 2H, H-2,6 in phenyl), 7.50 (d, J = 8.4 Hz, 2H, H-3,5 in phenyl), 8.43 (s, 1H, H-8). MS (ESI+) m/e: 641.9 (%100) (M+H), 643.9 (%48) (M+H+2).
30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Tuncbilek, Meral; Kucukdumlu, Asl?gul; Guven, Ebru Bilget; Altiparmak, Duygu; Cetin-Atalay, Rengul; Bioorganic and Medicinal Chemistry Letters; vol. 28; 3; (2018); p. 235 – 239;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics