30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1- (4- (trifluoromethyl) phenyl) piperazine (A-1, 43.7 mg, 0.19 mmol),1-((4-cyanophenyl) amino) cyclopentyl-1-carboxylic acid (B-1, 40.0 mg, 0.17 mmol), anhydrous triethylamine (35.4 mg, 0.35 mmol) was dissolved in 5 mL of anhydrous acetonitrile And anhydrous DMF in 1mL,Add 2- (7-benzotriazole) -N, N, N ?, N?-tetramethylurea hexafluorophosphate (HATU) (68.4mg, 0.18mmol), and react at room temperature for 30min. After the reaction, it was diluted with water and extracted with ethyl acetate. The organic layer was washed with dilute hydrochloric acid, sodium bicarbonate solution, and saturated brine in that order. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated. The concentrate was subjected to silica gel column chromatography (PE: EA = 2: 1, v / v) separation to obtain solid 1, yield 95.5%, 30459-17-7
As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.
Reference：
Patent; Hangzhou Weitan Pharmaceutical Technology Co., Ltd.; Cheng Yunfeng; Hu Yongzhou; (45 pag.)CN110357833; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics