169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Descriptions 150 (S)-tert-butyl 4-(5-chloro-2-methyl-3-nitrobenzyl)-2-methylpiperazine-1-carboxylate (DiSO)To a solution of 5-chloro-2-methyl-3-nitrobenzaldehyde (D143, 20 g) in DCM (260 mL), (S)-tertbutyl 2-methylpiperazine- 1 -carboxylate (24.08 g) was added. The mixture was stirred for 10 mm atroom temperture, sodium triacetoxyhydroborate (25.4 g) was added portionwise. The reaction mixtiure was stirred overnight at 20 C. The mixture was washed with brine, dried with anhydrous Na2SO4. Filtered, the filtrate was concentrated to give crude product, which was purified by column chromatography (silica gel, petroleum ether/EtOAc = 20:1) to afford the title compound (37 g) as white solid. MS (ESI): C18H26C1N3O4 requires 383; found 384 [M+Hf., 169447-70-5
The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DENG, Jing; LEI, Hui; MA, Xin; LIN, Xichen; WO2015/180612; (2015); A1;,
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