With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.
0.55 mmol of N-(5-piperon-4-tert-butylthiazol-2-yl)chloroacetamide, 0.83 mmol 1-ethylpiperazine, 0.8mmol triethylamine, Dissolved in 10 mL of tetrahydrofuran, Stir at room temperature for 12h The reaction solution was diluted with 50 mL of ethyl acetate. Wash once, Wash with saturated saline, Anhydrous Na2SO4 drying, Decompression distillation, Add a few drops of petroleum ether, Precipitation of solids, Suction filtration dry, In a white solid, 0.22 g of N-(5-piperon-4-tert-butylthiazol-2-yl)-2-(4-ethylpiperazinyl)acetamide was obtained. Yield 90%, 5308-25-8
5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Hunan University; Hu Aixi; Wu Zhilin; Ding Na; Ye Jiao; (20 pag.)CN107365280; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics