With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.
Cbz lnt-1 a A mixture of 5-fjiioro-2-nitrobenzaldehyde (20 g, 118 mmol) in DMF (150 mL), benzyl 1-piperazine carboxylate (31.2 g, 142 mmol), and triethylamine (14.3 g,142 mmol) was heated to 80 °C for 15 hours. After cooling to room temperature, the reaction mixture was diluted with EtOAc (300 mL), washed with brine (3 x 150 mL), dried over Na2S04, filtered, and concentrated. The resulting thick oil was purified by a flash column, eiuting with 20percent EtOAc/hexanes to yield 36.2 g (86percent) of Int-la as a yellow solid., 31166-44-6
The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; SCHERING CORPORATION; XIAO, Dong; PALANI, Anandan; ASLANIAN, Robert, G.; DEGRADO, Sylvia; HUANG, Xianhai; ZHOU, Wei; SOFOLARIDES, Michael; CHEN, Xiao; WO2011/75375; (2011); A1;,
Piperazine – Wikipedia
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