3022-15-9, Piperazine-2-carboxylic acid dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of piperazine-2-carboxylic acid dihydrochloride (4 g, 4.92 mmol) in dioxane-DMF (35 mL, 2.5:1) at 25C was added triethylamine (3.43 mL, 24.62 mmol) followed by benzyl chloride (25 mL, 24.62 mmol). After stirring at 1000C for 12h, the solution was cooled and partitioned between sat. NaCI aqueous solution and DCM. The aqueous layer was extracted several times with DCM. The combined organic fractions were dried (Na2SO4), concentrated and purified by column chromatography (silica, 5% ethyl acetate in hexane) affording the title compound as an off-white solid (1.2 g, 61 %): LCMS (ES) m/e 401 (M+H)+., 3022-15-9
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Reference：
Patent; GLAXO GROUP LIMITED; WO2006/20561; (2006); A2;,
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