With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Into a 250 mL round bottom flask was added 15L (10.93 g, 50.5 mmol) and 1,2- dichloroethane (144 mL). Acetic acid (3.03 g, 1 eq) was added and the flask was cooled to 0 C. Sodium triacetoxyborohydride (13.91 g, 1.3 eq) was slowly added. The flask was warmed to room temperature and stirred overnight at room temperature. The reaction mixture was poured onto saturated sodium bicarbonate. The organic layer was separated and the aqueous was extracted two times with ethyl acetate. The organic were combined and washed once with brine. The organics were dried over sodium sulfate and filtered. Solvent was removed under vacuum. The residue was purified by column chromatography with 50% ethyl acetate in hexanes to give a white solid 15N (13.07 g, 84%)., 314741-40-7
The synthetic route of 314741-40-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/89005; (2008); A2;,
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