55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a solution of 2-chloro-4-ethoxy-7-tosyl-7H-pyrrolo-[2,3-d]pyrimidine (which may be prepared according to 02) (1.0 eq), amines (1.0 eq) and xantphos (0.1 eq) in 1,4-dioxane (2.0 mL) and water (0.2 mL) was added potassium carbonate (2.0 eq) and PdCI2(pddf) (0.1 eq). The reaction mixture was stirred overnight at 90 C. The reaction was quenched with water and extracted with EtOAc (20 mL x 3). The combined organic layer was dried over Na2SO4, filtered and concentrated in vacuum. The crude was purified by columnchromatography on silica gel (DCM: MeOH=25:1)to give the desired products D96-D121., 55121-99-8
The synthetic route of 55121-99-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DING, Xiao; LIU, Qian; LONG, Kai; SANG, Yingxia; STASI, Luigi Piero; WAN, Zehong; XU, Qiongfeng; EDGE, Colin Michael; WO2015/113451; (2015); A1;,
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