50606-32-1,50606-32-1, Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1-methyl-2-{[methyl(5,6,7,8-tetrahydro-8-quinolinyl)amino]methyl}-1/-/-benzimidazole-7-carboxylic acid (105 mg, 0.3 mmol), bis(2-oxo-3-oxazolidinyl)phosphinic chloride(109 mg, 0.43 mmol), A/-butoxycarbonylpiperizine (80, 0.43 mmol), and N,N-diisopropylethylamine (56 mg, 0.43 mmol) were dissolved in acetonitrile (5 ml_) andA/,A/-dimethylformamide (2 ml_) and the reaction was stirred for 16 h at roomtemperature. The reaction mixture was concentrated and purified using reversephase HPLC (0% to 70% acetonitrile/water/0.1% trifluoroacetic acid gradient) toprovide the protected amine. The amine was dissolved in dichloromethane (2 mL)and trifluoroacetic acid (2 mL) and stirred for 3 h. The reaction was concentrated anddried to provide the product (30.0 mg, 13%) as a sticky yellow solid. 1H-NMR(DMSO-de) 5 9.01 (brs, 1H), 8.51 (d, 1H), 7.78-7.69 (m, 2H), 7.40-7.27 (m, 3H),5.01-4.90 (m, 1H), 4.81-4.71 (m, 1H), 4.59-4.52 (m, 1H), 4.00-3.84 (m, 2H), 3.62 (s,3H), 3.54-3.40 (m, 2H), 3.29-2.97 (m, 4H), 2.88-2.82 (m, 5H), 2.53-2.49 (m, 1H),2.16-2.06 (m, 2H), 1.82-1.69 (m, 1H). MS m/z419 (M+1).
50606-32-1 Butyl piperazine-1-carboxylate 21963126, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/23400; (2006); A2;,
Piperazine – Wikipedia
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