630125-91-6, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,630125-91-6
To a suspension of triphosgene (0.16 g, 0.53 mmol) and Na2C03 (0.67 g, 6.28 mmol) in DCM (10 ml) kept at 0 ocunder argon, 4-(4-ethyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenylamine (0.45 g, 1.57 mmol) was added. Thereaction was monitored by HPLC (following the formation of 4-ethyl-piperazine-1-carboxylic acid [4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide by treating a sample of the reaction mixture with Nethylpiperazine).After 1 h, 6-lodo-2,3-dihydro-1 H-indole (0.39 g, 1.61 mmol) was added and the reaction was letunder stirring 1 h at r.t. The mixture was diluted with DCM (10 ml), washed with water (3 x 10 ml), dried overanhydrous Na2S04 and concentrated under vacuum. Purification by flash column chromatography (DCM/MeOH 95/5)5 afforded the product as yellow foam (0.68 g, 77%).1H NMR (600 MHz, DMSO-dG) o ppm 1.00 (br. s., 3 H) 2.12-2.48 (m, 10 H) 3.15 (t, J=8.61 Hz, 2 H) 3.55 (br. s., 2 H)4.13 (t, J=8.70 Hz, 2 H) 7.03 (d, J=7.88 Hz, 1 H) 7.26 (dd, J=7.69, 1.65 Hz, 1 H) 7.64 (d, J=8.61 Hz, 1 H) 7.83 (d,J=8.43 Hz, 1 H) 7.97 (d, J=2.01 Hz, 1 H) 8.24 (d, J=1.28 Hz, 1 H) 8.84 (s, 1 H).
The synthetic route of 630125-91-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; MENICHINCHERI, Maria; ANGIOLINI, Mauro; BERTRAND, Jay Aaron; CARUSO, Michele; POLUCCI, Paolo; QUARTIERI, Francesca; SALOM, Barbara; SALSA, Matteo; ZUCCOTTO, Fabio; WO2014/72220; (2014); A1;,
Piperazine – Wikipedia
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