Downstream synthetic route of 4-((4-Methylpiperazin-1-yl)methyl)benzoic acid

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106261-48-7, 4-((4-Methylpiperazin-1-yl)methyl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Comparative Example 39: N’-(5-bromo-2-cyano-4-pyrimidinyl)-N’-(2,2-dimethylpropyl)-4-[(4-methyl-1-piperazinyl)methyl]benzohydrazide trifluoroacetate. [Show Image] Intermediate 49 (1 g, 4.3 mmol) was dissolved in thionyl chloride (5 ml). The reaction mixture was stirred at room temperature for 17 hours. The solvent was evaporated in vacuo and the acid chloride was used without any further purification.

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Reference:
Patent; GLAXO GROUP; EP1918284; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics