With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-66-2,(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
A Pyrex yessel was charged with magnetic stirring bar. (2.0 g. 11.42 mmol) of 2-methoxy-4-(oxiran-2-yl) benzonitrile, (3.70 g, 17.12 mmol) of tert-butyl (3R)-3-(hydroxymethyl)piperazine- 1 -carboxylate, and 6 m of EtOH. Then it was introduced in the microwaye reactor and irradiated at 150 C for 3 h. The mixture was cooled to room temperature and the solyent was eyaporated and the resulting residue was purified by column chromatography (silica gel, 1- 20% dichloromethane/MeOH) which afforded the product as a mixture of twodiastereomers (1:1) LCIMS: (IE, miz) [(M + 1) – t-Bu]± = 336.41
278788-66-2, As the paragraph descriping shows that 278788-66-2 is playing an increasingly important role.
Reference：
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DE JESUS, Reynalda, Keh; DING, Fa-xiang; DONG, Shuzhi; FRIE, Jessica; GU, Xin; JIANG, Jinlong; SHAHRIPOUR, Aurash; PIO, Barbara; TANG, Haifeng; WALSH, Shawn; WO2014/126944; (2014); A2;,
Piperazine – Wikipedia
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