74879-18-8,74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2.23 Example 23 (Prepared according to Scheme 4); (S)-4-(3-Chloropyridin-2-yl)-2-methyl-N-(4-(trimethylsilyl)phenyl)piperazine-l-carboxamide; A solution of 2,3-dichloropyridine (3mmol), (5)-(+)-2-methylpiperazine (3mmol) and TEA (9mmol) in DMSO (20 ml) was heated to 100 C for 18 hrs. The reaction mixture was diluted with MeOH (20 ml) and put onto an SCX cartridge. The cartridge was washed with MeOH before eluting the product off with 2M ammonia in MeOH. The appropriate fractions were collected and concentrated under reduced pressure. The resulting residue was purified by flash chromatography (60-80 % ethyl acetate in petroleum ether on KPNH cartridge) yielding (S)-l-(3-chloropyridine-2-yl)-3-methylpiperazine (2.1mmol).MS: ES+ 212.10. 1H NMR (400 MHz, DMSO-d6) delta 8.14 – 8.28 (m, IH), 7.67 – 7.87 (m, IH), 6.84 – 7.08 (m, IH), 3.49 – 3.62 (m, 2H), 2.87 – 2.96 (m, IH), 2.77 – 2.87 (m, 2H), 2.62 – 2.77 (m, IH), 2.51 (s, IH), 2.34 – 2.44 (m, IH), 0.92 – 1.10 (m, 3H)A solution of (,S>;-l-(3-chloropyridine-2-yl)-3-methylpiperazine (0.53mmol) and Intermediate 1 (0.53mmol) in ethanol (2 ml) was heated in the microwave to 100 0C for 30 min. The reaction mixture was concentrated under educed pressure and the resulting residue was purified by flash chromatography (20-40 % ethyl acetate in petroleum ether) yielding the title compound (0.32 mmol).MS ES- 401.20. 1H NMR (400 MHz, DMSO-d6) delta 8.32 (s, IH), 8.00 – 8.07 (m, IH), 7.57 – 7.66 (m, IH), 7.22 – 7.30 (m, 2H), 7.1 1 – 7.20 (m, 2H), 6.78 – 6.88 (m, IH), 4.26 (br. s., IH), 3.77 (br. s., IH), 3.41 – 3.52 (m, 2H), 2.98 – 3.08 (m, IH), 2.55 – 2.77 (m, 2H), 1.04 – 1.13 (m, 3H), 0.00 (s, 9H)
As the paragraph descriping shows that 74879-18-8 is playing an increasingly important role.
Reference：
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; AYSCOUGH, Andrew Paul; SHOWELL, Graham Andrew; TEALL, Martin Richard; TEMPLE, Hannah Elizabeth; AHMED, Saleh; WO2010/92342; (2010); A1;,
Piperazine – Wikipedia
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