59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
59702-07-7, Example 70: (+/-)-4-(c/’s-4-(4-amino-5-(2-phenylchroman-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-7- yl )cyclohexyl)- 1 – methyl piperazin-2-oneTo a mixture of 4-(4-amino-5-(2-phenylchroman-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-7- yl)cyclohexanone (Intermediate AL, 100 mg, 0.23 mmol), 1-methylpiperazin-2-one (137 mg, 0.92 mmol), diisopropyiethylamine (1.84 mmol, 327 uL) in dichloroethane (3 mL), was added sodium triacetoxyborohydride (195 mg, 0.92 mmol). The mixture was stirred at room temperature for 2 h and then concentrated. The resulting residue was purified to a mixture of the cis and trans isomers via reverse phase preparative HPLC (Method S). Preparative silica TLC, eluting with 10percent MeOH in DCM with 0.1 N ammonia, was used to isolate the cis (lower band) isomer. MS m/z 537.3 (M+H+) (Method M).
As the paragraph descriping shows that 59702-07-7 is playing an increasingly important role.
Reference：
Patent; NOVARTIS AG; IRM LLC, a Delaware Limited Liability Company; CHEN, Bei; FAIRHURST, Robin, Alec; FLOERSHEIMER, Andreas; FURET, Pascal; JIANG, Songchun; LU, Wenshuo; MARSILJE, Thomas, H.; VAUPEL, Andrea; WO2011/64211; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics