With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5747-48-8,11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine,as a common compound, the synthetic route is as follows.
5747-48-8, Step 4 (E)-2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethanol:; A mixture of (E)-11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine (1.00 g, 3.385 mmol), 2-bromoethanol (0.500 g, 4.00 mmol), anhydrous potassium carbonate (0.468 g, 3.386 mmol), sodium iodide (0.250 g, 1.67 mmol) and 1-butanol (20 mL) was heated at reflux for about 24 hours. The reaction mixture was filtered and the solid was washed with methanol. The combined filtrate and washings were concentrated to provide a crude residue. The residue was purified by chromatography on neutral alumina (2% methanol in dichloromethane) to afford the title product as an off-white solid (0.990 g, 86%). m.p. 57-60 C.; 1H NMR (400 MHz, pyridine-d5, 60 C.) delta 2.53-2.60 (m, 2H), 2.63-2.70 (m, 2H), 2.67 (t, J=5.9 Hz, 2H), 3.46-3.68 (m, 4H), 3.89 (t, J=5.9 Hz, 2H), 6.86-7.59 (m, 8H); IR (film) nu 3134, 1598, 1405, 1265 cm-1; MS 340 (M+1).
The synthetic route of 5747-48-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; AUSPEX PHARMACEUTICALS, INC.; US2010/69356; (2010); A1;,
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