With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.196811-66-2,tert-Butyl 4-carbamothioylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of 1-tert-butoxycarbonyl-4-thiocarbamoylpiperazine (Reference Example 150) (88mg, 0.35 mmol) in acetonitrile (20 ml) was added 1,2-bis(4-methoxyphenyl)-2-bromo-1-ethanone (Reference Example 14) (117 mg, mmol), and the mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated under a reduced pressure, and the residue was purified by chromatography (silica gel, n-hexane/ethyl acetate) to give a title compound (81 mg, 0.17 mmol, 48%) as a white solid. 1H-NMR (400 MHz, CDCl3) delta: 1.49 (9H, s), 3.47-3.61 (8H, m), 3.79 (3H, s), 3.81 (3H, s), 6.78 (2H, d, J = 8.8 Hz), 6.82 (2H, d, J = 8.8 Hz), 7.21 (2H, d, J = 8.8 Hz), 7.44 (2H, d, J = 8.8 Hz).
196811-66-2, As the paragraph descriping shows that 196811-66-2 is playing an increasingly important role.
Reference：
Patent; TORAY INDUSTRIES, INC.; EP2009006; (2008); A1;,
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