30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 5-methyl-3-isoxazole-4-carbonyl chloride (1.19g, 5.37mmol) in dioxane (15ml, anhydrous) was added dropwise to a cooled mixture (0C) containing l-(4-trifluoro- methylphenyl)-piperazine (1.24g, 5.38mmol commercially available) and pyridine (0.81ml, O.Olmol) in dioxane (25ml, anhydrous). The reaction solution was allowed to attain ambient temperature. Water was added to the solution affording a precipitation that was isolated by filtration. Re-crystallization from a mixture of MeOH/Acetonitrile (2: 1) afforded white crystalline compound (1.74g, 75%). 1H-NMR (400 MHz, DMSO-d6) delta 7.61-7.60 (m, 2H), 7.49-51 (m, 5H), 7.01-6.99 (m, 2H), 3.75 (br, 2H), 3.32 (br, 4H), 2.94 (br, 2H), 2.48 (s, 3H). 13C-NMR (400 MHz, DMSO-d6) delta 169.6(s), 162.4(s), 160.5(s), 153.6(s), 131.0(d), 129.8(d, 2H), 129.1(s), 128.2(d, 2C), 127.0 (q, 4JCF = 3.7 Hz, CCF3, 2C), 125.8 (q, lJ CF = 270.1 Hz, CCF3), 119.6 (q, 2JCF = 32.0 Hz, CCF3),115.4(d, 2C), 112.0(s), 48.0 (t, 4CH2), 12.1(q).
30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; VIRONOVA AB; HOMMAN, Mohammed; KINGI, Ngarita; BERGMAN, Jan; ENGQVIST, Robert; WO2013/171334; (2013); A1;,
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