21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: (1) Reaction. To a half-dram vial, in which reagent amine or its hydrochloride (0.050 mmol)was pre-weighed, were added 0.65 mL of a 0.1 M solution of 1-acryloyl-N,N-dimethylindoline-2-carboxamide (rac)-3 in 3.75% dry Et3Neanhydrous THF and 0.25 mL of 3.75% dry Et3N/dry dimethylacetamide and the resulting mixture was shaken at 60 C for 16 h. After cooling to room temperature, the reaction mixture was loaded onto an Oasis MCX cartridge (1 g/6 mL) preconditioned 8 mL of MeOH. The solid-phase matrix was washed with 10 mL of MeOH and then eluted with 5 mL of 1 M ammonia/MeOH. The elute was concentrated to dryness by vacuum centrifuge, providing crude product. In case it is needed, the crude material was purified with preparative LS/MS to give the desired product as salt-free form or formic acid salt dependent on the purification condition. (2) HPLC/LCeMS method. (i) Analytical condition: equipment, Waters 2795; column: Waters XTerra C18, 5 mm, 4.6 50 mm; column temperature, 40 C; detector, photodiodearray (210e400 nm); flow, 1.0 mL/min; solvent (a) as acidic condition, A: 0.1% HCO2H; B: MeOH, gradient, solvent (b) as basic condition, A: 0.1% aqueous ammonia; B: MeOH, gradient; MS condition (ionization method), ESI (positive). (ii) Preparativeconditions: equipment, Waters prep LC/MS system; column, Waters XTerra C18, 5 mm, 20 50 mm; column temperature, ambient temperature; flow, 20.0 mL/min; solvent (a) as acidic condition, A: 0.1% HCO2H; B: MeOH, gradient, solvent (b) as basic condition, A: 0.1% aqueous ammonia; B: MeOH, gradient., 21043-40-3
The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Hayashi, Shigeo; Ohashi, Katsuyo; Nakata, Eriko; Emoto, Chie; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 228 – 242;,
Piperazine – Wikipedia
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