With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.
In a three neck flask, under inert atmosphere (N2), is added 7.19g (27.2mmol) ofD in 150ml of DCM. The mixture is cooled to 0C. Then 5.75g (30mmol) of EDCI, 4.05g (30mmol) of HOBt and 3.85g (30mmol) of acetylpiperazine are added in this order. The temperature of 0C is maintained for 1 hour and the mixture is allowed to warm to 20C over 18 hours. Then 50ml of water are added and a solution of HCl 1M is added to obtain an acidic aqueous phase. The solution is extracted with DCM. The crude product is purified by column chromatography (Eluant: 90/10 DCM/MeOH) to give 9.04g (yield=89%) of the title compound, Example 115, as a white solid. NMR 1H (DMSO d6) : delta 2.04 (s, 3H), 3.62-3.40 (m, 8H), 4.10-3.85 (m, 2H), 4.12 (d, 1H), 4.30 (d, 1H), 6.62 (t, 1HAr), 6.95 (d, 1HAr), 7.26 (d, 1HAr), 7.48 (t, 1HAr), 7.70 (m, 2HAr), 7.77 (s, 1HAr)., 13889-98-0
As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.
Reference：
Patent; CEPHALON, INC.; CEPHALON FRANCE; EP1586559; (2005); A1;,
Piperazine – Wikipedia
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