30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Synthesis of new compounds 1-4 and 7-9 was performed bynucleophilic substitution (alkylation of amines) following theprocedure previously reported with certain modifications [43].Briefly, the corresponding ferrocene haloalkane (1.0 mmol), thesubstituted amine (1.0 mmol) and K2CO3 or NaH (2.0 mmol) weredissolved in THF (20 mL). The reaction was stirred at room temperatureuntil TLC (CH2Cl2/methanol or hexane/ethyl acetate)proved that the reaction did not go (about 48 h). THF was removedand the residue was diluted in CH2Cl2. The organic phase waswashed with water, dried over anhydrous Na2SO4, filtered, andevaporated. The residue obtained was purified either by automatedflash chromatography, eluting in gradient with CH2Cl2/methanol, orby precipitation with cold diethyl ether. Compounds 5 and 6 werepreviously characterized and evaluated as antibacterial agents [48].So, the general procedure for their synthesis was followed asdescribed by Damljanovic et al. with slight modifications [48]. Amixture of i3 (1.0 mmol), the corresponding amine (1.5 mmol) andMontmorillonite K10 (100 mg) was irradiated by microwave (50W,1.5 min). TLC was used to follow the reaction. The crude wasextracted with CH2Cl2 and evaporated on the rotary evaporator. Theresidue obtained was purified by automated flash chromatography,eluting in gradient with hexane/ethyl acetate. The final compoundwas precipitated with cold diethyl ether in order to obtain an orangepowder.
30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Paucar, Rocio; Martin-Escolano, Ruben; Moreno-Viguri, Elsa; Cirauqui, Nuria; Rodrigues, Carlos Rangel; Marin, Clotilde; Sanchez-Moreno, Manuel; Perez-Silanes, Silvia; Ravera, Mauro; Gabano, Elisabetta; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 569 – 582;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics