With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.192130-34-0,tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Preparation 20 tert-butyl 4-(2-{[(6′-{2-cyano-4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]phenoxy}-1,1′:3′,1″-terphenyl-3-yl)carbonyl]amino}ethyl)piperazine-1-carboxylate To a solution of 6′-{2-cyano-4-[(1 ,2,4-thiadiazol-5-ylamino)sulfonyl]phenoxy}-1 , 1′:3′, 1″- terphenyl-3-carboxylic acid (Preparation 21 , 100 mg, 0.18 mmol) in dimethylformamide (2.0 mL) was added 1 , T-carbonylbis(1 H-imidazole) (38 mg, 0.23 mmol) and N-ethyl-N- isopropylpropan-2-amine (35 mg, 0.27 mmol). The mixture was stirred at room temperature for 30 minutes, then tert-butyl 4-(2-aminoethyl)piperazine-1 -carboxylate (41.3 mg, 0.18 mmol) was added. The resulting reaction was stirred at room temperature for 3 days. The mixture was concentrated in vacuo to provide the title compound as an orange gum (204 mg, >100percent). This material was used in the next step without further purification. LCMS Rt = 2.40 minutes MS m/z 764 [M-H]”, 192130-34-0
The synthetic route of 192130-34-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; PFIZER INC.; SWAIN, Nigel Alan; BROWN, Alan Daniel; JONES, Lyn Howard; MARRON, Brian Edward; RAWSON, David James; RYCKMANS, Thomas; STORER, Robert Ian; WEST, Christopher William; WO2015/181797; (2015); A1;,
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