262368-30-9, N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone (1.1 g, 3.07 mmol) and (0.91 g, 3.49 mmol) N-[(4-methyl-piperazin-1-yl)-methylcarbonyl]-N-methyl-p-phenylendiamine are dissolved in 10 ml dimethylformamide and mixed for 1 hour at 80 C. ;After cooling, 0.8 ml piperidine is added and the reaction is further mixed for 2 hours at room temperature. Water is added, the supernatant is removed by suction, and the precipitate is washed again with a small quantity of water. The residue is suspended in 10 ml methanol, the supernatant is removed by suction, and the remaining residue washed with 2 ml cold water and 2 ml diethyl ether. The resulting product is vacuum dried at 110 C. Yield 1.3 g. LCMS: m/z=540 (MH)+. 1HNMR (300 MHz, CDCl3), delta 12.20 (1H, s), 11.10 (1H, s), 7.60 (5H, m), 7.40 (1H, s), 7.20 (3H, m), 6.90-7.00 (2H, d, J=8.7 Hz), 5.80-6.00 (1H, d, J=8.4 Hz), 3.80-3.90 (3H, s), 3.10 (3H, s), 2.70-2.80 (2H, s), 2.20 (11H, s)., 262368-30-9
262368-30-9 N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 21927707, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Auspex Pharmaceuticals, Inc.; Rao, Tadimeti; Zhang, Chengzhi; US2015/284327; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics