Month: June 2021

692058-21-2,692058-21-2, 1-Boc-4-(2,2,2-trifluoroethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-butyl 4-(2,2,2-trifluoroethyl)piperazine-1-carboxylate (253 mg, 0.94 mmol) was dissolve in DCM (9 mL) and a solution of 4 M HCI in dioxane (4.72 mL, 18.9 mmol) was added. The reaction was stirred 3 h at rt. The product was then concentrated in vacuum and co evaporated with DCM 3 times, affording the title compound (200 mg, 0.977 mmol, 100%) as beige solid.

The synthetic route of 692058-21-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; BANTAM PHARMACEUTICAL, LLC; SIDDIQUI, Arshad, M.; CIBLAT, Stephane; DERY, Martin; CONSTANTINEUA-FORGET, Lea; GRAND-MAITRE, Chantal; BRUNEAU-LATOUR, Nicolas; SHIPPS, Gerald, W.; COOPER, Alan, B.; OZA, Vibha; KOSTURA, Matthew, W.; LUTHER, Michael; LEVINE, Jedd; (174 pag.)WO2018/102453; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-70-5,(S)-tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

^-ieri-Butyl 2-methyl-4-(pyridin-2-yl)piperazine-l-carboxylateTo a solution of ieri-butyl (25)-2-methylpiperazine-l-carboxylate (8 g, 39.94 mmol) in DMSO (25 ml) was added 2-bromopyridine (6.594 g, 41.74 mmol), and DIEA (15.48 g, 119.78 mmol). After stirring 2 days at 120C, the resulting solution was quenched by the addition of DCM (200 ml), washed with water (3 x 300 ml), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford a residue, which was purified via silica gel chromatography (3% ethyl acetate in petroleum ether) to afford (S)-tert- butyl 2-methyl-4-(pyridin-2-yl)piperazine-l-carboxylate as a red oil (5.2 g, 47%).LC/MS (ES, m/z): [M+H]+ 278.0’H-NMR (300 MHz, CDC13) delta 8.18 – 8.20 (t, J = 1.8 Hz, 1H), 7.46 – 7.52 (m, 1H), 6.60 – 6.64 (m, 2H), 4.33 – 4.35 (m, 1H), 4.08 – 4.15 (m, 1H), 3.91 – 4.00 (m, 2H), 3.19 – 3.31 (m, 2H), 2.92 – 3.01 (m, 1H), 1.50 (s, 9H), 1.27 – 1.30 (t, / = 4.5 Hz, 3H)

169447-70-5, Big data shows that 169447-70-5 is playing an increasingly important role.

Reference：
Patent; BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C.; WO2012/119046; (2012); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

304897-49-2, tert-Butyl 4-(4-aminobenzyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

d: Ethyl 4-(4-((4-(tert-butoxycarbonyl)piperazin- 1 -yl)methyl)phenylamino)-2-chloro- 6-methylpyrimidine-5-carboxylate Ethyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate (0.5 g, 2.1 mmol) and tert-butyl 4-(4-aminobenzyl)piperazine-l-carboxylate (0.6 g, 2.06 mmol) were dissolved in NMP and stirred at 0C for 2 hour. The reaction mixture was poured onto water and extracted with EtOAc. The organic layer was washed with water, dried over a2S04 and evaporated under vacuum to get the desired compound (0.62 g). XH NMR (400 MHz, CDC13): delta 10.58 (s, 1H), 7.58 (d, J = 6.4 Hz, 2H), 7.31 (d, J = 6.4 Hz, 2H), 4.45 (q, J = 6.8 Hz, 2H), 3.56 (s, 2H), 3.41 (m, 4H), 2.69 (s, 3H), 2.47 (m, 4H), 1.45 (s, 9H), 1.43 (t, J = 6.8 Hz, 3H); MS m/z 490.0 (M+l).

304897-49-2, As the paragraph descriping shows that 304897-49-2 is playing an increasingly important role.

Reference：
Patent; ENDO PHARMACEUTICALS INC.; VENKATESAN, Aranapakam; SMITH, Roger, Astbury; HOSAHALLI, Subramanya; POTLURI, Vijay; PANIGRAHI, Sunil, Kumar; BASETTI, Vishnu; KUNTU, Karunasree; WO2013/28818; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5317-33-9

Example 33; 4-(3-Chloro-phenyl)-2-{6-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzoimidazol-1-yl}-thiazole-5-carboxylic acid amide (I.33); Step 1; To a mixture of 0.158 g (1 mmole) of 3-(4-methyl-piperazin-1-yl)-propan-1-ol, and 5 mL of pyridine was added 0.001 g of 4-dimethylaminopyridine and 0.190 g (1 mmole) of p-toluenesulphonyl chloride. The mixture was stirred at ambient temperature overnight and then concentrated under reduced pressure. The residue was taken up in 20 mL of dichloromethane and washed once with 10 mL of saturated sodium bicarbonate, twice with 10 mL of water, and then brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 0.248 g of 3-(4-methyl-piperazin-1-yl)-propyl ester as a colorless oil.

The synthetic route of 5317-33-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Cai, Jianping; Chen, Shaoqing; Chen, Yi; Chu, Xin-Jie; Goodnow, JR., Robert Alan; Le, Kang; Luk, Kin-Chun; Mischke, Steven Gregory; Wovkulich, Peter Michael; US2010/160308; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,934-98-5

General procedure: General procedure: a suspension of the indenoquinoline 20 or 23(1.67 mmol) and the appropriated amine (3.33 mmol) in 7 ml ofdry pyridine was heated at 100 C for 20 h. The reaction mixturewas poured into iced water (150?200 ml) and when it was possible,the precipitate was filtered, otherwise it was extracted withethyl acetate or dichloromethane. The organic layer was dried withanhydrous Na2SO4 and evaporated to dryness. The residue waspurified by CC (silica gel; CH2Cl2/MeOH or cyclohexane/ethyl acetatein gradient as indicated for each compound).

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Article; Barteselli, Anna; Parapini, Silvia; Basilico, Nicoletta; Mommo, Danilo; Sparatore, Anna; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 5757 – 5765;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122323-88-0,Methyl piperazine-2-carboxylate dihydrochloride,as a common compound, the synthetic route is as follows.

REFERENCE EXAMPLE 16 A solution of di-tert-butyl dicarbonate (5.0 g) in dichloromethane (30 ml) is added dropwise, taking one hour at 0 C. while stirring, to a mixture of methyl piperazine-2-carboxylate dihydrochloride (5.0 g), triethylamine (7 g) and dichloromethane (70 ml). The reaction mixture is poured into ice-water and extracted with dichloromethane. The organic layer is washed with water and dried, then the solvent is distilled off under reduced pressure. The residue is purified by means of a silica gel column chromatography (eluent, dichloromethane:acetone:ethanol =5:5:1) to afford methyl 4-tert-butoxycarbonylpiperazine-2-carboxylate as a colorless oily product (4.9 g).

122323-88-0, 122323-88-0 Methyl piperazine-2-carboxylate dihydrochloride 2760425, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Takeda Chemical Industries, Ltd.; US4997836; (1991); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.138775-02-7,(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

(2,S)-4-Benzyloxycarbonyl-l-/er/-butoxycarbonyl-piperazine-2-carboxylic acid (5.0 g, 13.72 mmol) was dissolved in anhydrous THF (70 mL) and cooled to 0 C with an ice bath. Borane dimethyl sulfide complex (2.6 mL, 27.44 mmol) was added dropwise at 0 C, slowly. Then the reaction solution was left to warm up to room temperature and stirred overnight. The reaction mixture was then cooled to 0 C with an ice bath and quenched with water, dropwise, and extracted with EtOAc. The aqueous phase was extracted with DCM (2x). Combined organic layers were dried over anhydrous MgS04, filtered and evaporated under reduced pressure. It was used without further purification.

138775-02-7, The synthetic route of 138775-02-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; EMORY UNIVERSITY; LIOTTA, Dennis C.; JECS, Edgars; ALTAS TAHIROVIC, Yesim; WILSON, Lawrence; PELLY, Stephen Christopher; (102 pag.)WO2019/183133; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weighing 2-methoxy-4 – (4-methyl piperazin-1-yl) aniline (12C) (2.21g, 10mmol), the 100 ml round-bottom flask. N sequentially adding to the reaction bottle, N-dimethylformamide (20 ml), 2, 4, 5-trichloro-pyrimidine (1.83g, 10mmol) and potassium carbonate (1.79g, 13mmol). The reaction temperature is increased to 80 C stirring 4 hours. After cooling to room temperature to be reacted, the reaction solution is poured into ice water (50 ml), the residue is extracted with methylene chloride (100 ml × 2), the combined organic phase with saturated salt water (50 ml × 2), dried anhydrous sodium sulfate, after concentrating under reduced pressure, the residue is separated by silica gel column chromatography (dichloromethane/methanol (v/v) =15:1) to obtain the title of yellow solid product 2,5-dichloro-N-(2-methoxy-4 – (4-methyl piperazin-1-yl) phenyl) pyrimidin-4-amine (12D) (3.4g, yield: 92.5%), 122833-04-9

As the paragraph descriping shows that 122833-04-9 is playing an increasingly important role.

Reference：
Patent; Four Chuanhaisike Pharmaceutical Co., Ltd.; Li, Yao; Weiy, Onggang; Zang, Guobiao; Li, Guanpeng; Hu, Shihong; (73 pag.)CN105384694; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

182181-38-0, 3-Fluoro-4-(piperazin-1-yl)benzonitrile is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,182181-38-0

tert -Butyl 4-(4-nitrophenyl)piperazine-1-carboxylate (XVII: X=H): To a solution of 1-(nitrophenyl)piperazine (20.7,0.1 mol) and triethylamine (21 ml) in dichloromethane (250 ml) at 0-5 C was added dropwise a solution of di-tert-butyldicarbonate in dichloromethane (50 ml). The resulting mixture was stirred at 0-5 C for 2 h and at room temperature for 18 h. Then the reaction mixture was diluted with 100 ml of chloroform, washed with water, brine and dried over sodium sulphate. The solvent was removed under reduced pressure and the residue was triturated with hexane and hexanelethyl acetate mixture to give the title compound as a yellow solid (29 g, 94%). 1H NMR (CDCl3) delta: 1.5 (s, 9H, 3XCH3), 3.43 (t, 4H, 2XCH2), 3.6 (t, 4H, 2XCH2), 6.8 (d, 2H, Ar-H, J=9 Hz), 8.15 (d, 2H, Ar-H, J=9 Hz).

The synthetic route of 182181-38-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Naeja Pharmaceutical Inc.; TAIHO PHARMACEUTICAL CO., LTD.; EP889881; (2003); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235865-77-6,2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.

Formula 2(100 g) and triethylamine (35.2 g) was stirred in dichloromethane (500 mL). In another flask, formula 9(46.9 g), 4-dimethylaminopyridine (42.68 g), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide(46.96 g) in dichloromethane (1.2 L) was stirred. The solution of formua-2 was added slowly to the solution of formula 9 at ambient temperature and the reaction was stirred for 12 hours. The organic layer was washed with 10% acetic acid solution (750 mL) twice, followed by 5% aqueous NaHCO3 (750 mL) and 5% aqueous NaCI (750 mL). The dichloromethane layer was concentrated under vacuum at 40C. Dichloromethane (900 mL) was added and the r eaction mixture was heated to 38C. Methanol (100 mL) and ethyl acetate (800 mL) were added at 38 The reaction mass was cooled to 27±3C, stirred for 2 hours, and filtered. The solid was washed with a mixture of dichloromethane (150 mL) and ethyl acetate (150 mL). The solid was dried under vacuum at 60±5C for 4 hours. Dry weight: 76 g (Yie Id = 50%)., 1235865-77-6

As the paragraph descriping shows that 1235865-77-6 is playing an increasingly important role.

Reference：
Patent; MYLAN LABORATORIES LIMITED; JOSHI, Rajesh; TRIPATHI, Anil Kumar; CHAUDHARI, Chandrakant; GOTTUMUKKALA, Nagaraju; POKHARKAR, Kiran; SANGVIKAR, Yogesh; VADALI, Lakshmanarao; JAYACHANDRA, Suresh Babu; (48 pag.)WO2018/29711; (2018); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics