Month: June 2021

303-26-4, 1-((4-Chlorophenyl)(phenyl)methyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2 10 gr. of (0.035 mole) of 1-[(4-chlorophenyl)phenylmethyl]piperazine, 8.06 gr. (0.0525 mole) of methyl 2-chloroethoxyacetate and 50 ml. of triethylamine were introduced into a pressure vessel and treated in a similar way as described in example 1. 12.5 gr. of methyl [2-[4-[(4-chlorophenyl)phenylmethyl]- 1-piperazinyl]ethoxy]acetate is obtained as reddish oil (88.7% yield)., 303-26-4

As the paragraph descriping shows that 303-26-4 is playing an increasingly important role.

Reference：
Patent; Chemagis Ltd.; EP952153; (1999); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

(iii) 3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsulfinyl)phenyl)ureido)naphthalen-1- yl)oxy)pyridin-2-yl)amino)-5-methoxy-N-(2-(4-methylpiperazin-1-yl)ethyl)benzamideHATU (150 mg, 0.394 mmol) was added to a solution of the product from step (ii) above (200 mg, 0.284 mmol), 2-(4-methylpiperazin-1-yl)ethanamine (60 mg, 0.419 mmol) and diisopropylethylamine (150 L, 0.859 mmol) in DMF (2 mL). The reaction mixture was stirred at rt for 72h. Water (10 mL) added and the resulting solid filtered off, washed with water (2 mL) and dried to afford the title compound (0.19 g). 1H NMR (400 MHz, DMSO-ds) delta 9.41 (s, 1 H), 9.07 (s, 1 H), 8.96 (s, 1 H), 8.51 (d, 1 H), 8.28 (d, 1 H), 8.21 (t, 1 H), 8.12 (d, 1 H), 8.10 (d, 1 H), 7.88 (d, 1 H), 7.77-7.67 (m, 1 H), 7.66-7.58 (m, 1 H), 7.56 (t, 1 H), 7.50 (t, 1 H), 7.40 (d, 1 H), 7.36 (d, 1 H), 6.86 (dd, 1 H), 6.58 (dd, 1 H), 6.14 (d, 1 H), 3.87 (s, 3H), 3.74 (s, 3H), 2.79 (s, 3H), 2.43 (t, 2H), 2.32 (s, br, 10H), 2.15 (s, 3H), 1.32 (s, 9H). LCMS m/z 794 (M+H)+(ES+)

934-98-5, As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; FYFE, Matthew Colin Thor; THOM, Stephen Malcolm; BAKER, Thomas Matthew; HARBOTTLE, Gareth William; HASIMBEGOVIC, Vedran; RIGBY, Aaron; WO2015/92423; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.,74879-18-8

(2S)-2-methylpiperazine (15 g, 150 mmol) was dissolved in tetrahydrofuran (300 mL) and the solution was cooled down to 0 C. Sodium hydroxide (150 mL, 449 mmol) was added, then 4-(trifluoromethyl)benzenesulfonyl chloride (40 g, 164 mmol) (dissolved in 200 ml THF) was added dropwise and the resulting mixture was stirred for 1 h. Further 4-(trifluoromethyl)benzenesulfonyl chloride (0.06 eq, 2.2 g) was added and mixture stirred for 10 min. The mixture was diluted with DCM (500 ml) and water (500 ml) and stirred for 5 min. The phases were separated, the aqueous layer was extracted with DCM (1000 ml) and the organic phases concentrated under reduced pressure. The residue was taken-up with 1 M HCl (500 ml) and washed with DCM in order to extracted impurities. The aqueous phase was basified to pH=9 with NaOH 3M, extracted with DCM (3×500 ml) and the combined organic phases dried over Na2SO4 before the solvent was removed under reduced pressure to give the title compound (30 g).m/z (API-ES) 309 [M+H]+ 1H NMR (400 MHz, CDCl3) delta ppm 1.06 (d, J=7.2 Hz, 3H), 1.94 (t, J=10.4 Hz, 1H), (td, J=11.2, 4.0 Hz, 1H), 2.88-3.07 (m, 3H), 3.66 (m, 2H), 7.83 (d, J=8.4 Hz, 2H), 7.90 (d, J=8.4 Hz, 2H).

74879-18-8 (S)-(+)-2-Methylpiperazine 2734219, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Beswick, Paul John; Campbell, Alister; Cridland, Andrew; Gleave, Robert James; Heer, Jag Paul; Nicholson, Neville Hubert; Page, Lee William; Vile, Sadie; US2010/22555; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142-64-3,Piperazine Dihydrochloride,as a common compound, the synthetic route is as follows.

A 250 mL round bottom flask was charged with 20 mmol of compound (4), 80 mL of 1,4-dioxane,20 mmol of compound (2) (R is methyl) was added dropwise at 20 C under stirring for 1 hour. The mixture was heated to reflux for further stirring. After about 6 hours, the solid was no longer increased but changed to distilled. The methanol was distilled off to recover the compound (2) (R is methyl), cooled to below 30 , 40mmol sodium methylate in methanol 30% sodium methoxide was added dropwise over about 1 hour and then stirred for 1 hour, the temperature was rectified methanol were recovered, 1 , 4-dioxane and piperazine (3). The product was distilled off under reduced pressure to give a pale yellow transparent liquid to obtain piperazine methylmethyldimethoxysilane (R is methyl) represented by the formula (1) a, the yield of 95% (as (2) dollars), high performance liquid chromatography analysis content of 98.7%.

142-64-3, The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Yancheng Technology College; Sun Guoxiang; (6 pag.)CN106046041; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.350684-49-0,tert-Butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: The mixture of compound 10a-10e (3.24 mmol), compound 9(1.04 g, 3.4 mmol), Pd(OAc)2 (0.11 g, 0.5 mmol), Xantphos (0.28 g,0.5 mmol), and K3PO41.38 g, 6.48 mmolin DMF (8 mL) was heated 22 h at 125 C under argon followed by cooling to roomtemperature.The mixture was extracted with dichloromethane(20 mL x 3), the combined organic phase was washed with water(15mL x 2), dried over anhydrous Na2SO4 and concentrated toafford the crude product. The crude product was purified by columnchromatography to obtain compounds 11a-11e. 4.1.6.1. Tert-butyl 4-(4-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin -2-yl)amino)benzoyl)piperazine-1-carboxylate(11a). Yield 62%. MP: 227-228 C. 1H NMR (400 MHz, DMSO-d6)delta 11.64 (s, 1H), 9.73 (s, 1H), 8.77 (dd, J = 17.2, 4.4 Hz, 2H), 8.28 (s, 1H),7.78 (d, J = 8.8 Hz, 3H), 7.56-7.52 (m, 1H), 7.36 (d, J = 8.4 Hz, 2H),7.17 (t, J = 7.2 Hz, 1H), 3.50-3.36 (m, 8H), 2.83 (d, J = 4.4 Hz, 3H),1.42 (s, 9H).13C NMR (100 MHz, DMSO-d6) delta169.32, 168.87, 157.39,155.07, 154.53, 153.83, 141.78, 139.15, 131.45, 127.99, 122.13, 121.58, 121.01, 118.47, 105.80, 79.16, 43.56, 42.90, 28.02, 26.31., 350684-49-0

350684-49-0 tert-Butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate 2763355, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Su, Yue; Li, Ridong; Ning, Xianling; Lin, Zhiqiang; Zhao, Xuyang; Zhou, Juntuo; Liu, Jia; Jin, Yan; Yin, Yuxin; European Journal of Medicinal Chemistry; vol. 177; (2019); p. 32 – 46;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59702-07-7, A mixture N [5-chloro-7- (3-methoxyprop-1-yn-1-yl)-1, 3-benzodioxol-4-yl]-7- (3- chloropropoxy) -5-isopropoxyquinazolin-4-amine (0.320 g, as a 1: 1.3 wt.: wt. mixture with triphenylphosphine) and 1-methylpiperazin-2-one (0.280 g) was dissolved in 2- methoxyethanol (7 ml), then sodium iodide (0.040 g) was added and the reaction mixture was then heated at 110°C with stirring for 24 hours. The reaction mixture was then cooled to room temperature, diluted with dichloromethane (70 ml) and washed with water: brine (1: 1) then water then brine and dried over magnesium sulfate before filtration and evaporation of solvents under reduced pressure. The residues so resulting were then purified by column chromatography on silica using increasingly polar mixtures of methanol in dichloromethane as eluent. There was thus obtained 4- (3- {4- [5-chloro-7- (3-methoxy-prop-1-ynyl)- benzo [1, 3] dioxol-4-ylamino]-5-isopropoxy-quinazolin-7-yloxy}-propoxy)-1-methyl- piperazin-2-one (0.086 g) as a white foam; NMR Spectrum: (CDC13) 1.53 (d, 6H), 2.02 (quin, 2H), 2.61 (t, 2H), 2.72 (t, 2H), 2.96 (s, 3H), 3.18 (s, 2H), 3.33 (t, 2H), 3.45 (s, 3H), 4.15 (t, 2H), 4.35 (s, 2H), 4.83 (sept, 1H), 6.10 (s, 2H), 6.49 (d, 1H), 6.82 (d, 1H), 7.05 (s, 1H), 8.51 (s, 1H), 9.41 (s, 1H); Mass Spectrum: M+H+ 596/598.

As the paragraph descriping shows that 59702-07-7 is playing an increasingly important role.

Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/4732; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

70261-82-4, STEP-1: To the solution of compound 1 (16.7 g, 73 mmol) and NaHCO3 (18.5 g, 219 mmol) in anhydrous DMF, was added sodium chloroacetate 2 (12.8 g, 109.5 mmol). After the addition, the mixture was stirred at 75 C. for 2 h, and to the resultant mixture, was added compound 3 (15 g, 73 mmol) in portion at the same temperature and the solution was stirred for 4 h. The mixture was cooled to room temperature and poured into ice water. The resultant precipitate was filtered, washed with water and dried to give target compound. Quantity: 20 g; yellow solid; yield: 75%.

70261-82-4 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 3153996, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Burlison, Joseph A.; Zhang, Shijie; Ying, Weiwen; Chimmanamada, Dinesh U.; Song, Minghu; Chae, Junghyun; Schweizer, Stefan M.; US2010/113447; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13754-38-6, 1-Benzoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of 2-chloroalkyl/aryl substitutedwith or without N-substitution as well as with or without 5 and/or 6-substituted benzimidazole derivative (1.75g,0.01051mol) and 1-[(4-phenyl)carbonyl]piperazine (3g,0.0105mol) in N, N dimethylformamide was taken in a RBF.K2CO3(2gm,) was added to the reaction mixture. The reaction mixture was stirred for 8h at 80C on a magnetic stirrer (heat + stirring). The progress of the reaction was monitored by thin layer chromatography (TLC).Upon completion of the reaction, water was added to the reaction mixture and the product extracted by shaking the reaction mixture with dichloromethane in a separating funnel.The dichloromethane layer was washed successively with water and brine, dried over anhydrous sodium sulfate. Evaporation of the solvent gave theproduct. 11a-l Recrystallized with various solvent like chloroform, ethanol, methanol., 13754-38-6

As the paragraph descriping shows that 13754-38-6 is playing an increasingly important role.

Reference：
Article; Kankate, Rani S.; Gide, Parag S.; Belsare, Deepak P.; Oriental Journal of Chemistry; vol. 30; 4; (2014); p. 1855 – 1863;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

[14031 Step 1: Synthesis of (E?)-methyl3-(4-(((3R.55?)-3 .5-dimethylpiperazin- 1 -yl?)methyl?)phenyl?)acrylate [14041 (2S ,6R)-2,6-dimethylpiperazine (0.500 g, 4.379 mmol), (E)-methyl3-(4-(bromomethyl)phenyl)acrylate (formula 8-4, 1.173 g, 4.598 mmol) and Cs2CO3 (2.140 g, 6.568 mmol) were dissolved in acetonitrile (10 mL) at room temperature, and the reaction solution was stuffed at the same temperature for 5 hours. Then, the reaction mixture was filtered through a glass filter to remove solids, and the filtrate was con-centrated under reduced pressure. The concentrate was purified by column chromatography (silicon dioxide, 12 g cartridge; methanol/methylene chloride = from 0 percent to 15 percent) and concentrated to afford the desired compound (1.090 g, 86.3 percent) as an orange solid., 21655-48-1

21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; SONG, Hyeseung; LEE, Changgon; KWAK, Dalyong; LEE, Jaeyoung; BAE, Suyeal; KIM, Yuntae; BAE, Daekwon; HA, Nina; BAE, Miseon; KIM, Jihyun; WO2015/137750; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

In a sealed tube, 7-fluoro-2-(2-methylimidazo [1 ,2-b]pyridazin-6-yl)-4H-pyrido [1,2- a]pyrimidin-4-one (Intermediate 1; 50 mg, 0.169 mmol), and cis-2,6-dimethylpiperazine (77mg, 0.677 mmol, 4.0 eq.) were stirred in DMSO (2 mL) at 110C overnight. The solvent was removed under high vacuum. The residue was taken up in CH2C12 and washed with an aqueous saturated solution of NaHCO3. The organic layer was separated and dried over Na2504 and concentrated in vacuo. The crude was purified by column chromatography (5i02, CH2C12/MeOH=95/5 to 90/10) to afford the title product (41 mg, 62%) as a light yellow solid.MS m/z 390.3 [M+H?i., 21655-48-1

As the paragraph descriping shows that 21655-48-1 is playing an increasingly important role.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ALSENZ, Jochem; GRASSMANN, Olaf; KUEHL, Peter; METZGER, Friedrich; MCCARTHY, Kathleen Dorothy; MORAWSKI VIANNA, Eduardo Paulo; WOODHOUSE, Marvin Lloyd; (130 pag.)WO2017/80967; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics