Month: June 2021

70261-81-3, 1-Methyl-4-(4-nitrobenzyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

70261-81-3, To the 500 mL single neck flask was added 8.5 g (36.2 mmol) of crude I-a,FeO (OH) / C catalyst 2.0 g and 95% ethanol 100 mL,Heating reflux,A mixture of 25 mL of hydrazine hydrate and 20 mL of 95% ethanol was slowly added dropwise,TLC detects the disappearance of the starting material (methanol: chloroform = 1:15).The filter cake was washed twice with hot ethanol (30 mL x 2)The solvent was evaporated under reduced pressure to give a white solid,And dried in vacuo to give 6.7 g of (I-b) in a yield of 90.3%.Products without further purification, directly into the next step.

The synthetic route of 70261-81-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; China Pharmaceutical University; Lu Shuai; Wang Yue; Zhi Yanle; Yao Chao; Lu Tao; Li Baoquan; Chen Puzhou; Bao Jiyin; (27 pag.)CN107245073; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.303-26-4,1-((4-Chlorophenyl)(phenyl)methyl)piperazine,as a common compound, the synthetic route is as follows.

Example 4 10 gr. (0.035 mole) of 1-[(4-chlorophenyl)phenylmethyl]piperazine, 8.8 gr. of ethyl 2-chloroethoxyacetate, 0.4. gr. of tetrabutylammonium iodide and 50 ml. of triethylamine were introduced into a pressure vessel and treated as described in example 1. 13.2 gr. of ethyl [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetate is obtained (90.8% yield).

303-26-4, The synthetic route of 303-26-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Chemiagis, Ltd.; US6100400; (2000); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

162046-66-4, 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,162046-66-4

A solution of 4-8a (8.9 g, 24.4 mmol) in a mixture of ethanol (100 mL) and ethyl acetate (25 mL) was hydrogenated under an atmosphere of hydrogen gas at 45 psi in the presence of 5% Pd/C (0.89 g) at RT for 1.5 h. The resultant mixture was filtered through a plug of Celite, and the filtrate concentrated under vacuum. The residue was redissolved in toluene and concentrated under vacuum to provide the corresponding aniline. A solution of 4-[4-(tert-butyloxycarbonyl)piperazin-1-yl]-benzoic acid (4-2 wherein R2 =H) (1.0 g, 3.3 mmol) in dichloromethane (25 mL) and DMF (3 drops) at RT was treated with oxalyl chloride (0.43 mL, 4.9 mmol) over a period of 10 min. The resultant solution was stirred at RT for 1 h, and concentrated under vacuum. The residue was dissolved in toluene and concentrated to remove residual oxalyl chloride. The resultant acid chloride 4-9 was redissolved in dichloromethane (5 mL), and added to a cold (0 C.) solution the above aniline (1.1 g, 3.3 mmol) and DMAP (0.48 g, 3.9 mmol) in dichloromethane (25 mL). The resultant mixture was stirred at RT overnight, diluted with dichloromethane and washed successively with 10% aq citric acid, sat. sodium bicarbonate, and brine. The organic extract was dried over magnesium sulfate, filtered and concentrated under vacuum. The residue was subjected to column chromatography on silica gel eluding with 50% ethyl acetate in hexane. Collection and concentration of appropriate fractions provided 4-10a as a gum. STR42 Step 3: N-{4-[4-(Piperazin-1-yl)phenylcarbonylamino]phenyl}-N-phenyl-sulfonylglycine (4-11a)

As the paragraph descriping shows that 162046-66-4 is playing an increasingly important role.

Reference：
Patent; Merck & Co., Inc.; US5780480; (1998); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Into a reactor with a working volume of 1000 mL equipped with a thermometer, a reflux condenser and a mechanical stirrer, DMSO (480 mL), l-cyclopropyl-6,7-difluoro-l,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid (138.0 g; 0.4675 mole) and 2-methylpiperazine (94.0 g; 0.9387 mole) were put at 25C (20C-30C). The reaction mixture was stirred for 30 minutes at 25C (20C-30C). Then it was heated in 50 minutes (45-60 minutes) to the temperature of 73C. The reaction mixture was stirred at this temperature for 12 hours. After 12 hours at 73C, the reaction mixture was cooled to 25C in 45 minutes (40-50 minutes). The pH of the suspension was measured and adjusted to the pH value of 10.2 with a 15% HC1 solution (27.5 mL of 15% HC1) and the suspension was stirred for 24 hours. The pHof the suspension was periodically checked and adjusted to the desired value of 10.2 if necessary. When adjusting the pH vapours were formed, which were sucked off by underpressure and led through a trap with a solution of calcium hydroxide, which irreversibly bound fluoride ions. The product was then filtered over a filter MN 640 (black ribbon) and washed with methanol (165 mL). The product was thoroughly sucked off and the humidity was determined. Estimated yield of the dry gatifloxacin base: 52.0-54.7%., 109-07-9

As the paragraph descriping shows that 109-07-9 is playing an increasingly important role.

Reference：
Patent; KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO; WO2006/4561; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

78818-15-2, Benzyl 3-oxopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,78818-15-2

b) 2-Bromoethyl di-tert-butyl phosphate (298mg, 0. 94MMOL) in tetrahydrofuran (1. 0ml) was added at room temperature to a stirred suspension of benzyl 3-oxopiperazine-1- carboxylate (200mg, 0. 85mmol), powdered potassium hydroxide (57mg, L. OMMOL) and tetra- n-butylammonium bromide (55mg, 0.17mmol) in THF (2. 0ml). The reaction mixture was -266- stirred for 90 minutes and then filtered through Celite and the filtrate evaporated to leave a colourless oil. The crude product was purified by silica gel chromatography eluting with a 2- 5% mixture of methanol in dichloromethane to give benzyl 4-{2-[(DI-TERT- butoxyphosphoryl) oxy] ETHYL}-3-OXOPIPERAZINE-1-CARBOXYLATE (220 mg, 55% yield) as a colourless oil: 1H-NMR (CDC13) : 7.34 (m, 5H), 5.16 (s, 2H), 4.15 (s, 2H), 4.11 (m, 2H), 3.71 (m, 2H), 3.65 (m, 2H), 3.53 (m, 2H), 1.47 (s, 18H).

The synthetic route of 78818-15-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/94410; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-78-2,tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

[00203] Under a N2 atmosphere tert-butyl 2-methylpiperazine-l-carboxylate (2.0 mmol), (E)-(3-bromoprop-l-en-l-yl)benzene (2.4mmol), K2CO3 (3 mmol) were combined in a vial, CH3CN (2 mL) was added, and the reaction mixture was stirred at 60 C overnight, The crude reaction mixture was diluted with EtOAc and washed with H20 and brine. The organic layer was dried over Na2S04, filtered and condensed. The crude mixture was purified using flash silica gel column chromatography to get the pure product tert-butyl 4-cinnamyl-2- methylpiperazine-l-carboxylate (yield 70%).

120737-78-2, As the paragraph descriping shows that 120737-78-2 is playing an increasingly important role.

Reference：
Patent; THE GENERAL HOSPITAL CORPORATION; PETERSON, Randall T.; RENNEKAMP, Andrew J.; KOKEL, David; (121 pag.)WO2015/200674; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: One-pot synthesis of N-(aminosulfonyl)-4-podophyllotoxin carbamates from PPT in the presence of CSI and amine via the Burgess-type intermediates.1 CSI (170 mg, 1.2 mmol) was added dropwise to a solution of PPT (500 mg, 1.2 mmol) in DCM (5 mL) at -10. The reaction mixture was stirred at -10 for 30 min. Pyridine (1.0 equiv) was then added dropwise to above mixture and stirred for another 1 h at -10. Followed amine (2.0 equiv) was added to the reaction mixture at -10. The reaction mixture was stirred for 2 h at -10, then stirred at room temperature until the reaction was finished. The reaction mixture was washed in order by distilled water and saturated brine, and then the extract was dried over MgSO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography, using CH2Cl2/acetone as the eluent, to afford pure compounds 5-13.

21043-40-3, As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference：
Article; Xu, Xiao-Hui; Guan, Xiao-Wen; Feng, Shi-Liang; Ma, You-Zhen; Chen, Shi-Wu; Hui, Ling; Bioorganic and Medicinal Chemistry Letters; vol. 27; 13; (2017); p. 2890 – 2894;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.,76003-29-7

-(tert-Butyloxycarbonyl)-piperazin-2-one (8.0 g, 40 mmol), EXAMPLE 40, is dissolved in THF (160 mL), cooled in an ice bath and treated with 60% sodium hydride (1.9 g, 48 mmol). The reaction mixture is stirred 40 minutes, then treated with tetra-butylammon

76003-29-7 1-Boc-3-Oxopiperazine 3157178, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; AVENTIS PHARMACEUTICALS INC.; US2004/102450; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5747-48-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5747-48-8,11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine,as a common compound, the synthetic route is as follows.

A 1 liter round bottom flask equipped with stirring rod, thermo pocket, water condenser was charged with solution of l l-piperazinyldibenzo[b,f] [l,4]thiazepine in toluene 350 cc [63.0 g (0.22 moles)] and the mixture was stirred for 15 min 25- 30C, and was added sodium carbonate [41.0 gm (0.39 moles)], tetra butyl ammonium bromide [16.0 gm (0.05 mole)] and 2-(2-chloroethoxy)ethanol [32.0 gm (0.257 moles)] at room temperature. The reaction mixture was heated to reflux at 110- 112C. The reaction mixture was maintained at reflux for 10-12 hrs. The reaction mixture was analyzed by HPLC (to check for absence of compound of Formula IV) and was cooled to 25C to 30C. To which, was added 150 cc DM water, then the reaction mixture was stirred for 30 min at 25-30C. The layers were separated and the aqueous layer extracted with 50 cc toluene. The extract and the organic layer were combined, to which was added 250 cc water and was acidified with acetic acid to obtain a pH of 2-3. The reaction mixture was stirred for 30 min at 25-30C. The layers were separated and the aqueous layer washed with 100 cc toluene twice. To the aqueous layer was added 250 cc toluene, and the pH was adjusted to 8-10 using sodium carbonate, the reaction mixture was stirred for 30 min at 25-30C. The layers were separated and the aqueous layer extracted with 125 cc toluene. The extract and the organic layer were combined, to which was washed with DM (dimineralized) water 300 cc twice. The organic layer was distilled off under vacuum below 70C to afford 2-(2-(4-dibenzo[b,f]-[l,4] thiazepine-l l-yl-l-piperazinyl)ethoxy) ethanol. Purity of 2-(2-(4-dibenzo[b,fj-[l,4] thiazepine-l l-yl-l-piperazinyl)ethoxy) ethanol was 99.0% (area % by HPLC).

The synthetic route of 5747-48-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2008/121415; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54699-92-2,4-Methyl-1-piperazineacetic acid,as a common compound, the synthetic route is as follows.

54699-92-2, 36) 2-(4-methylpiperazin-1-yl)acetyl chloride [Show Image] Oxalil chloride (0.3 ml, 3.47 mmol) was added dropwise to a stirred solution of (4-Methyl-piperazin-1-yl)-acetic acid (500 mg, 3.16 mmol) 15 ml of dry THF and placed under inert atmosphere. Two drops of dimethylformammide were added. The reaction mixture was refluxed for 1 h, and the solvent removed under reduced pressure giving 440 mg (80%) (4-Methyl-piperazin-1-yl)-acetyl chloride as a yellow solid. 1H-NMR (DMSO, 400 MHz), delta (ppm): 3.20 (2H, s), 2.78 (8H, m), 2.60 (3H, s).

54699-92-2 4-Methyl-1-piperazineacetic acid 2762732, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Universita Degli Studi Di Milano – Bicocca; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD – LYON 1; EP2107054; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics