Month: June 2021

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

A solution of DIPEA (690 mul, 3.97 mmol) and 1-cyclopropylpiperazine (500 mg, 3.97 mmol) in acetonitrile (5 ml) was added to a solution of 2-chloro-5-nitropyridine (631 mg, 3.97 mmol) in acetonitrile (10 ml). The mixture was stirred at rt for 4 hours and then concentrated to dryness. The residue was diluted with DCM and 2M sodium carbonate solution (aq). The organic phase was dried and concentrated to give a yellow solid (912 mg, 93%). 1H NMR (400 MHz, DMSO-cfe) delta ppm 0.31 – 0.49 (m, 4 H), 1.65 (it, ./=6.70, 3.38 Hz, 1 H), 2.52 – 2.69 (m, 4 H), 3.61 – 3.82 (m, 4 H), 6.95 (d, 7=9.62 Hz, 1 H), 8.21 (dd, 7=9.62, 2.75 Hz, 1 H), 8.95 (d, 7=2.75 Hz, 1 H); m/z (ES+APCI)+: 249 [M+H]+., 20327-23-5

As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.

Reference：
Patent; MEDICAL RESEARCH COUNCIL; WO2009/122180; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5747-48-8, 11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5747-48-8

Example 3: l-(4-Dibenzo[b,f] [l,4]thiazepin-ll-yl-piperazin-l-yl)-ethanoneA solution of PDBTZ (1 mmol) (lmmol) in DMF (2 mL) is treated with acetic anhydride (2 mmol) and heated for one hour. The reaction mixture is evaporated to dryness, made basic with aqueous potassium carbonate, and extracted with dichloromethane. The organic portion is washed (water, brine), dried (sodium sulfate), and evaporated. The crude material is purified by flash chromatography to provide the title compound.

The synthetic route of 5747-48-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ASTRAZENECA AB; WO2008/79838; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.,21043-40-3

1-Cyclopentyl piperazine (700?mg, 4.5?mmol) was added to a stirred solution of 1 (1?g, 3.0?mmol) in 15?mL dry 1,4-dioxane and DIPEA (0.8?mL, 4.5?mmol). The solution was stirred for 6?h?at room temperature. The reaction mixture was concentrated under reduced pressure and poured into ice water and extracted with ethyl acetate (3?*?50?mL). The combined organic part was washed with water followed by brine, dried over sodium sulphate and concentrated under reduced pressure. The crude residue was purified by flash column chromatography, eluting with 2-5% methanol in chloroform to provide pure compound 36 as white solid (940?mg, 86% yield, m.p- 156-160?C). 1H NMR (300?MHz, CDCl3) delta 7.47-7.44 (m, 2H), 7.41-7.32 (m, 3H), 7.18 (s, 1H), 7.06 (s, 1H), 5.25 (s, 2H), 3.96 (s, 3H), 3.79 (t, J?=?4.8?Hz, 4H), 2.67 (t, J?=?4.8?Hz, 4H), 2.58-2.53 (m, 1H), 1.94-1.85 (m, 2H), 1.76-1.66 (m, 2H), 1.60-1.53 (m, 2H), 1.47-1.40 (m, 2H). 13C NMR (75?MHz, CDCl3) delta 164.3, 154.8, 154.1, 150.5, 148.6, 135.4, 128.7, 128.3, 127.4, 109.1, 108.4, 103.6, 70.8, 67.6, 56.2, 51.8, 48.9, 30.0, 24.0. HRMS (EI) calcd for C25H29ClN4O2 (m/z) [M]+ 452.1979; found 452.1987.

As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference：
Article; Paul, Barnali; Rahaman, Oindrila; Roy, Swarnali; Pal, Sourav; Satish, Sohal; Mukherjee, Ayan; Ghosh, Amrit R.; Raychaudhuri, Deblina; Bhattacharya, Roopkatha; Goon, Sunny; Ganguly, Dipyaman; Talukdar, Arindam; European Journal of Medicinal Chemistry; vol. 159; (2018); p. 187 – 205;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example No. 125Preparation of N- (4- (4-ethylpiperazin-l-yl) phenyl) -5-(imidazo [1, 2-a] pyridin-2-yl) -lH-pyrazolo [4, 3-d] pyrimidin-7- amine7-chloro-5- (imidazo [1, 2-a] pyridin-2-yl) -2- (4 -methoxybenzyl) – 2H-pyrazolo [4 , 3-d] pyrimidine (0.16 mmol) and 4- (4- ethylpiperazin-l-yl) aniline (0.3 mmol 2 eq.,) were suspended in MeOH (dry, 3mL) in a microwave vial (2-5mL) , HC1 in dioxane (4M, 3 drops) was added. The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 1 0C. The reaction mixture was concentrated and purified by semi- preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 439.2607 g/mol HPLC-MS: analytical method Crt: 1.787 min – found mass: 440 (m/z+H)

115619-01-7, The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ORIGENIS GMBH; ALMSTETTER, Michael; THORMANN, Michael; TREML, Andreas; TRAUBE, Nadine; WO2012/143144; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.

HATU (184 mg, 0.48 mmol) was added to a stirred mixture of 4-(6-mefhyl-7-oxo-6,7-dihydro- lH-pyrrolo[2,3-c]pyridin-4-yl)benzoic acid (Intermediate D) (100 mg, 0.37 mmol), 1 – mefhylpiperazin-2-one (63 mg, 0.56 mmol), and diisopropylethylamine (168 mg, 1.30 mmol) in DMF (5 mL). The reaction mixture was stirred at room temperature for 8 h, at which time (0597) LCMS indicated that the reaction had gone to completion. The reaction mixture was partitioned between ethyl acetate (20 mL) and water (15 mL). The separated organic solution was washed with brine (2 x 10 mL), dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by preparative HPLC, acetonitrile : water (10 nM ammonia bicarbonate) 35percent-65percent, to afford the title compound (47.9 mg, 15.8percent yield) as a white solid. 1H NMR (400 MHz, DMSC 5): 3 12.14 (s, 1 H), 7.66 (d, J= 8.4 Hz, 2 H), 7.52 (d, J- 8.4 Hz, 2 H), 7.45 (s, 1 H), 7.35 (s, 1 H), 6.47 (d, J= 2.0 Hz, 1 H), 4.12-4.09 (m, 4 H), 3.56-3.50 (m, 2 H), 3.47 (s, 3 H), 2.85 (s, 3 H). LCMS M/Z (M+H) 365.1. The following compounds were prepared in a similar fashion to Example 26: Examples 27-38, 59702-07-7

59702-07-7 1-Methylpiperazin-2-one 4399042, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; BELLON, Steven, F.; BURDICK, Daniel, J.; COTE, Alexandre; CRAWFORD, Terry; DAKIN, Les, A.; HEWITT, Michael, Charles; HSIAO-WEI TSUI, Vickie; LEBLANC, Yves; MAGNUSON, Steven, R.; NASVESCHUK, Christopher, G.; ROMERO, F. Anthony; TANG, Yong; TAYLOR, Alexander, M.; WANG, Shumei; (128 pag.)WO2016/77380; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228780-72-0,1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine,as a common compound, the synthetic route is as follows.

Example 33G ethyl 2-(1H-indol-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)benzoate EXAMPLE 33A (225 mg), EXAMPLE 33F (240 mg), and HK2PO4 (131 mg) were stirred in dimethylsulfoxide (4 mL) at 135 C. for 24 hours. The reaction was diluted with ethyl acetate, washed three times with water, washed with brine, dried, and concentrated. The crude product was chromatographed on silica gel with 30% ethyl acetate/hexanes., 1228780-72-0

As the paragraph descriping shows that 1228780-72-0 is playing an increasingly important role.

Reference：
Patent; ABBOTT LABORATORIES; US2010/184766; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Substituted amine (1.2 equiv) was added to a mixture of 4-fluoronitrobenzene (1 equiv) and K2CO3 (2.0 equiv) in DMF (7mL/g). The reaction mixture was stirred at 40C and followed by TLC. After completion of the reaction, the mixture was poured into stirring ice-water. The resulting precipitate was filtered and dried to obtain compounds 11 as a yellow solid., 21043-40-3

As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference：
Article; Hou, Yunlei; Zhu, Liangyu; Li, Zhiwei; Shen, Qi; Xu, Qiaoling; Li, Wei; Liu, Yajing; Gong, Ping; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 690 – 709;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.

(c) (R)-4-[5-(4-Bromo-2-chloro-5-trifluoromethoxy-phenylcarbamoyl)-pyridin-2-yl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester To a reaction mixture of the product of the previous step (999 mg, 2.42 mmol) in a mixture of N,N-diisopropylethylamine (0.84 mL, 4.83 mmol;) and DMSO (0.86 mL, 12.08 mmol) was added (R)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (726 mg, 3.62 mmol) and the reaction mixture was heated at 120 C. overnight and extracted with ethyl acetate/water. The organic layer was dried over sodium sulfate and concentrated under vacuum. The dark oil was dissolved in a small amount of DCM and purified by silica gel chromatography (24 g column, 0-40% ethyl acetate:hexanes) to produce the title intermediate as a white solid (916 mg, 64% yield). (m/z): [M+H]+ calcd for C23H25BrClF3N4O4 593.07; 595.07. found 595.4., 163765-44-4

163765-44-4 (R)-1-Boc-3-Methylpiperazine 2756811, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; LONG, Daniel D.; MCKINNELL, Robert Murray; JIANG, Lan; LOO, Mandy; LEPACK, Kassandra; VAN ORDEN, Lori Jean; OGAWA, Gavin; HUANG, Xiaojun; ZHANG, Weijiang; US2013/115194; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

To the 25 ml round-bottom flask by adding 69A (159mul, 1mmol) and dichloromethane, after stirring to dissolve by adding 69B (270 mg, 1mmol), then adding STAB (254 mg, 1 . 2mmol) stirring overnight, TLC detection reaction is complete, water washing, the water layer is extracted with ethyl acetate, combined with the phase, saturated salt water washing, dry anhydrous sodium sulfate, concentrated after the silica gel to obtain the product 69 (217 mg, 56%).

21043-40-3, 21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Chengdu Biological Technology Co., Ltd. Kerry Bass; Li, Dequn; (92 pag.)CN105777632; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 1-substituted piperazines (1.5mmol), carbon disulfide (0.45mL, 7.5mmol) and finely powered anhydrous potassium phosphate (0.32g, 1.5mmol) in DMF (7.5mL) was stirred at room temperature for 30min. 6-(Bromomethyl)-2,4-diaminoquinazoline (7) (0.38g, 1.5mmol) was added to the solution, and stirring was continued at room temperature for 4h. After poured into water (100mL), the resulting precipitate was collected by filtration, which was purified by column chromatography (CC) on silica gel or recrystallization from appropriate solvent to give compounds 8a-u., 115761-79-0

115761-79-0 1-(2,4-Difluorophenyl)piperazine 2734637, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Cao, Sheng-Li; Han, Ying; Yuan, Chong-Zhen; Wang, Yao; Xiahou, Zhi-Kai; Liao, Ji; Gao, Rui-Ting; Mao, Bei-Bei; Zhao, Bao-Li; Li, Zhong-Feng; Xu, Xingzhi; European Journal of Medicinal Chemistry; vol. 64; (2013); p. 401 – 409;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics