169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
[0144] Step 6a: (S)-tert-Butyl 4-acryloyl-2-methylpiperazine-1-carboxylate . Acryloyl chloride (1.3 mL, 16.5 mmol) was added to a solution of (S)-1-Boc-2-methyl-piperazine (3.00 g, 15.0 mmol, Boc Sciences, Shirley, NY) in THF (30 mL) at-10 C, and the resulting mixture was stirred at-10 C for 5 min. Triethylamine (6.3 mL, 44.9 mmol) was then slowly added, and the resulting mixture was stirred at-10 C for 15 min, then allowed to warm to rt. The reaction mixture was partitioned between EtOAc and saturated aqueous NaHCO3. The aqueous layer was extracted with EtOAc, and the organic layers were then combined, dried over MgSO4, filtered, and concentrated in vacuo. The crude product was purified by silica gel chromatography (eluent: 0-100% EtOAc/heptane) to provide (S)-tert-butyl 4-acryloyl-2- methylpiperazine-1-carboxylate: 1H NMR (400 MHz, DMSO-d6) d 6.72- 6.85 (m, 1H) 6.10 – 6.18 (m, 1H) 5.68- 5.76 (m, 1H) 4.08- 4.32 (m, 2H) 3.68- 4.03 (m, 2H) 2.86- 3.14 (m, 2H) 2.66- 2.80 (m, 1H) 1.38- 1.43 (s, 9H) 0.96- 1.04 (m, 3H). m/z (ESI, +ve ion): 277.3 (M+Na)+.
169447-70-5, As the paragraph descriping shows that 169447-70-5 is playing an increasingly important role.
Reference：
Patent; AMGEN INC.; ALLEN, John Gordon; ALLEN, Jennifer Rebecca; MINATTI, Ana Elena; XUE, Qiufen; WURZ, Ryan Paul; TEGLEY, Christopher M.; PICKRELL, Alexander J.; NGUYEN, Thomas T.; MA, Vu Van; LOPEZ, Patricia; LIU, Longbin; KOPECKY, David John; FROHN, Michael J.; CHEN, Ning; CHEN, Jian Jeffrey; SIEGMUND, Aaron C.; AMEGADZIE, Albert; TAMAYO, Nuria A.; BOOKER, Shon; GOODMAN, Clifford; WALTON, Mary; NISHIMURA, Nobuko; SHIN, Youngsook; LOW, Jonathan D.; CEE, Victor J.; REED, Anthony B.; WANG, Hui-Ling; LANMAN, Brian Alan; (738 pag.)WO2019/213516; (2019); A1;,
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