50606-32-1, Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,50606-32-1
2-{[Methyl(5,6,7,8-tetrahydro-8-quinolinyl)amino]methyl}-1H-benzimidazole-4-carbaldehyde (100 mg, 0.30 mmol), /V-butoxycarbonylpiperizine (115 mg, 0.60mmol), acetic acid (28 mg, 0.47 mmol) and sodium triacetoxyborohydride (100 mg,0.47 mmol) were dissolved in 1,2-dichloroethane (10 ml_) and stirred for 16 h at roomtemperature. The reaction concentrated and purified using reverse phase HPLC (0%to 70% acetonitrile/water/0.1% trifluoroacetic acid gradient) to provide the protectedamine. The carbamate was dissolved in dichloromethane (2 ml_) and trifluoroaceticacid (2 ml) and stirred for 3 h at room temperature. The reaction was concentrated,dissolved in water and lyophilized to provide the product (68 mg, 30%) as an off-white solid: 1H-NMR (DMSO-d6) 5 8.62 (d, 1H), 7.94 (d, 1H), 7.72 (d, 1H), 7.58-7.54(m, 1H), 7.41-7.35 (m, 2H), 4.74-4.70 (m, 1H), 4.60 (d, 1H), 4.48 (d, 1H), 4.38 (s,2H), 3.25 (br s, 4H), 3.13 (br s, 4H), 2.88-2.80 (m, 2H), 2.65 (s, 3H), 2.36-2.30 (m,1 H), 2.08-1.96 (m, 2H), 1.82-1.72 (m, 1 H). MS m/z 391 (M+1).
As the paragraph descriping shows that 50606-32-1 is playing an increasingly important role.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/23400; (2006); A2;,
Piperazine – Wikipedia
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