78551-60-7, tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 24:4-benzyl-4,7-diaza-spiro[2.5]octane-7-carboxylic acid tert-butyl esterTo EtMgBr (344 mL) in THF cooled to -78C was added Ti(0’Pr)4 (39 g, 137.93 mmol), followed by commercially available 4-benzyl-3-oxo-piperazine-l-carboxylic acid tert- butyl ester (40 g, 137.93 mmol) and the resultant reaction mixture was heated to reflux for 1 h. After cooling the reaction mixture to 5C, another portion of EtMgBr (344 ml) and Ti(0’Pr)4 (39 g, 137.93 mmol) was added. The mixture was stirred for 16 h at RT. The reaction mixture was quenched with NH4CI solution and stirred for 15 min and filtered through a celite bed and washed with EtOAc. The aqueous layer was again extracted with EtOAc (3 x). The combined EtOAc layers were washed with water and dried over Na2S04 and concentrated under reduced pressure. Purification by column chromatography to afforded the title compound as a solid (24 g, 58%).XH NMR (300 MHz, DMSO) delta = 7.20 (m, 5H), 3.80 (s, 2H), 3.40 (m, 2H), 3.22 (m, 2H), 2.63 (m, 2H), 1.38 (s, 9H), 0.58 (br, 4H), 78551-60-7
78551-60-7 tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate 10891590, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; LEO PHARMA A/S; SCHOU, S°ren Christian; GREVE, Daniel Rodriguez; NIELSEN, Simon Feldbaek; JENSEN, Jens Bj°rn; DACK, Kevin Neil; WO2012/93169; (2012); A1;,
Piperazine – Wikipedia
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