31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation 7.2Oxetan-3-ylpiperazine.2.6 g of 3-oxetanone, 1 .0 g of sodium cyanoborohydride and 0.16 ml of acetic acid are added to a solution of 2.0 g of benzyl piperazine-1 -carboxylate in 20 ml of acetonitrile and then stirred for 16 hours at RT. The reaction mixture is diluted with water and filtered through a Chem Elut.(R). cartridge, eluting with DCM. The combined organic phases are dried over MgSO4 and the solvent is evaporated under vacuum. The residue is purified by preparative HPLC and1 .7 g of a white solid is obtained. 0.5 g of this solid is dissolved in 20 ml of EtOH, 0.2 g of Pd/C at 10percent is added and the mixture is stirred under a hydrogen atmosphere (4 bar) for 3 hours. The reaction mixture is filtered on Celite.(R). and the filtrate is concentrated under vacuum. The expected compound is obtained.
31166-44-6, 31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; SANOFI; BADORC, Alain; BOLDRON, Christophe; DELESQUE, Nathalie; FOSSEY, Valerie; LASSALLE, Gilbert; YVON, Xavier; WO2012/146318; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics