With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.
Synthesis of compound 189.2. To a solution of 1-isopropylpiperazine (0.35 g, 2.7mmol, l .Oeq) in CH3CN (5ml) was added potassium carbonate (1.12g, 8.1mmol, 3.0eq). Compound 189.1 (0.5 g, 2.7 mmol, l .Oeq) in CH3CN (5 ml) was added dropwise to the reaction mixture. Reaction mixture was then stirred at 60°C for 6 hours. After completion of the reaction, mixture was poured into water and product was extracted with EtOAc. Organic layers were combined, washed with brine, dried over Na2S04 and concentrated under reduced pressure to obtain crude which was purified by column chromatography to furnish 189.2 (0.460 g, 61.56percent). MS (ES): m/z 277.32 [M+H]+.
4318-42-7, 4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; NIMBUS LAKSHMI, INC.; MASSE, Craig E.; GREENWOOD, Jeremy Robert; ROMERO, Donna L.; HARRIMAN, Geraldine C.; WESTER, Ronald T.; SHELLEY, Mee; KENNEDY-SMITH, Joshua Jahmil; DAHLGREN, Markus; WO2015/131080; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics