30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A mixture of carboxylic acid 6 (3.5 mol), EDC*HCl (5.4 mol), HOBt (5.4 mol) in anhydrous DMF (20 mL) was stirred at RT. Substituted piperazine (3.5 mol) was then added and the mixture was further stirred at RT for 10-12 hr40. After completion of the reaction as indicated by TLC, the reaction mixture was quenched in crushed ice. The precipitated solid was washed with NaHCO3 and dil. HCl. The product thus obtained was purified by silica gel column chromatography using hexane: ethyl acetate as eluent., 30459-17-7
The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Raundal, Hemant N.; Jadhav, Rahul P.; Patil, Amar A.; Bobade, Vivek D.; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 54B; 8; (2015); p. 979 – 987;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics