350684-49-0, tert-Butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of r -butyl 4-(4-aminobenzoyi)piperazine- 1-carboxylate (2d, 1.7 g, 5.7 mmol, 1 equiv ), 3,5-dibromo-l-methylpyrazin-2(lH)-one (2e, 1.8 g, 6.8 mmol, 1.2 equiv.) and N,N-diisopropylethylamine (1.48 mL, 8.5 mmol, 1.5 equiv.) in N,N-dimethylacetamide (5 mL) was stirred in a sealed vial at 105 C for 30 h. The reaction was cooled to room temperature and EtOAc (20 mL) was then added. The solid precipitate was filtered and dried on high vacuum overnight to provide tert-butyi 4-(4-((6-bromo-4-methyl-3-oxo-3,4- dihydropyrazin-2~yl)amino)benzoy)piperazine-I -carboxylate 2f. The product was carried onto the next step without further purification., 350684-49-0
The synthetic route of 350684-49-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael S.; WANG, Jinhua; DOBROVOLSKY, Dennis; (224 pag.)WO2019/148150; (2019); A1;,
Piperazine – Wikipedia
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