With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142-64-3,Piperazine Dihydrochloride,as a common compound, the synthetic route is as follows.
100 g (1.2 mol) of anhydrous piperazine and 240 g (1.5 mol) of piperazine dihydrochloride were heated to 120 C, and 150 g (1.2 mol) of 2-(2-chloroethoxy)ethanol was added dropwise. After the completion of heating and stirring, the temperature was raised to 136-140 C for 1 hour, and TLC showed that the reaction was completed and then the heating was stopped. When the temperature dropped to 80 degrees Celsius, 500ml of 95% ethanol was added, cooled in the refrigerator overnight, and the piperazine dihydrochloride was recovered by filtration the next day. The filter cake was washed thoroughly with a small amount of ethanol, the filtrate was combined, and 200 g of 30% sodium hydroxide solution was added, alkalized, and the insoluble inorganic salt was filtered off, and concentrated to remove the solvent. The residue was extracted with ethyl acetate, dry hydrogen chloride gas was passed, filtered and dried to give a white solid 1-[2-(2-hydroxyethoxy)ethyl]piperazine hydrochloride. The solid content was already above 98%. After recrystallization from a 90% aqueous solution of ethanol, 207 g of white crystals can be obtained, the yield was 70%, and the content can be more than 99.5%., 142-64-3
The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Wuxi Qianhao Bio-pharmaceutical Co., Ltd.; Peng Haiyan; (4 pag.)CN109400549; (2019); A;,
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