With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: A mixture of 1-substituted piperazines (1.5mmol), carbon disulfide (0.45mL, 7.5mmol) and finely powered anhydrous potassium phosphate (0.32g, 1.5mmol) in DMF (7.5mL) was stirred at room temperature for 30min. 6-(Bromomethyl)-2,4-diaminoquinazoline (7) (0.38g, 1.5mmol) was added to the solution, and stirring was continued at room temperature for 4h. After poured into water (100mL), the resulting precipitate was collected by filtration, which was purified by column chromatography (CC) on silica gel or recrystallization from appropriate solvent to give compounds 8a-u., 115761-79-0
115761-79-0 1-(2,4-Difluorophenyl)piperazine 2734637, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Cao, Sheng-Li; Han, Ying; Yuan, Chong-Zhen; Wang, Yao; Xiahou, Zhi-Kai; Liao, Ji; Gao, Rui-Ting; Mao, Bei-Bei; Zhao, Bao-Li; Li, Zhong-Feng; Xu, Xingzhi; European Journal of Medicinal Chemistry; vol. 64; (2013); p. 401 – 409;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics