With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-78-2,tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
[00203] Under a N2 atmosphere tert-butyl 2-methylpiperazine-l-carboxylate (2.0 mmol), (E)-(3-bromoprop-l-en-l-yl)benzene (2.4mmol), K2CO3 (3 mmol) were combined in a vial, CH3CN (2 mL) was added, and the reaction mixture was stirred at 60 C overnight, The crude reaction mixture was diluted with EtOAc and washed with H20 and brine. The organic layer was dried over Na2S04, filtered and condensed. The crude mixture was purified using flash silica gel column chromatography to get the pure product tert-butyl 4-cinnamyl-2- methylpiperazine-l-carboxylate (yield 70%).
120737-78-2, As the paragraph descriping shows that 120737-78-2 is playing an increasingly important role.
Reference：
Patent; THE GENERAL HOSPITAL CORPORATION; PETERSON, Randall T.; RENNEKAMP, Andrew J.; KOKEL, David; (121 pag.)WO2015/200674; (2015); A1;,
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