With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142-64-3,Piperazine Dihydrochloride,as a common compound, the synthetic route is as follows.
217 mg (1 mmol) of alkaloid and 183 mg (1.5 mmol)Monopiperazine hydrochloride was added to 10 mL of methanol and 62 mg (0.1 mmol)In the mixed system of Yb(OTf)3, the reaction was stirred at room temperature for 3 days, and the reaction was completed by TLC.Add 100 mg (1.2 mmol) of NaHCO3 powder and continue to stir for 12 h.Concentrate to dryness under reduced pressure and add 10 mL of benzene to residue.After stirring for 10 min, it was quickly demineralized by a neutral Al2O3 column, concentrated, and purified by silica gel column chromatography (benzene: acetone: ammonia = 10:1:2) to obtain intermediate (III) in a yield of 79%.
142-64-3, As the paragraph descriping shows that 142-64-3 is playing an increasingly important role.
Reference：
Patent; Shijiazhuang College; Zhang Baohua; Shi Lanxiang; (8 pag.)CN109776575; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics