With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5747-48-8,11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine,as a common compound, the synthetic route is as follows.
Example 1: l-(4-Dibenzo[b,f| [l,4]thiazepin-ll-yl-piperazin-l-yl)-2-methyl-propan-l-oneAn ice-bath-cooled solution of 1 l-iperazin-l-yldibenzo[b,f][l,4]thiazepine (“PDBTZ”, 1 mmol) and triethylamine (1.1 mmol) in dichloromethane (5 mL) is treated with 2-methylpropionic acid chloride (1.1 mmol). The mixture is warmed to ambient temperature and stirred for one hour. Water is added and the mixture is extracted with dichloromethane. The organic portion is washed (brine), dried (sodium sulfate), and evaporated. The crude material is purified by flash chromatography to provide the title compound., 5747-48-8
Big data shows that 5747-48-8 is playing an increasingly important role.
Reference：
Patent; ASTRAZENECA AB; WO2008/79838; (2008); A1;,
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