With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.
Combine 6- (4-formyl-phenoxy)-nicotinamide (compound of example 332, step 1) (0.303 g, 1.25 mmol) and 1-cyclopentyl piperazine (0.198 g, 1.28 mmol) in methanol (11 ML) and stir. After 15.5 h, add sodium borohydride (0.109 g, 2.88 mmol), and stir at ambient temperature. After 1 h, concentrate the reaction mixture and purify by silica gel chromatography (ethyl ACETATE- 4: 1 ethyl acetate: methanol) to provide 0.172 g (36%) of the title compound as an off white solid: high resolution mass spectrum (electrospray): M . TALC for C22H29N402 381. 2291, found 381.2306 ; 1H NMR (DMSO-D6) : 8.66 (d, 1H, J = 2. 4 HZ), 8. O0 (dd, 1H, J = 2. 9,8. 8 Hz), 7.48-7. 43 (M, 2H), 7.18-7. 13 (m, 2H), 7.04 (d, L H, J = 7.8 Hz), 3.61 (s, 2H), 3.00-2. 25 (m, 9H), 2.01-1. 88 (m, 2H), 1.82-1. 69 (m, 2H), 1.69-1. 56 (m, 2H), 1.53-1. 38 (m, 2H).
21043-40-3, The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ELI LILLY AND COMPANY; WO2004/26305; (2004); A1;,
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