With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.
1- (2, 4-Difluoro-phenyl) -piperazine (3.3 mmol; prepared by reacting piperazine with 1-BROM-2, 4-difluorobenzene according to the procedure described in WO 01/92264) was dissolved in 20 mL of THF and 1.1 eq. OF PROPARGYL bromide was added, followed by [how much?] eq. of anhydrous K2CO3. The reaction mixture was stirred at room temperature for 18 hours. It was then diluted with EtOAc and washed with brine, dried with Na2SO4 and concentrated to afford 1-(2, 4-difluoro-phenyl) -4-prop-2- ynyl-piperazine., 115761-79-0
The synthetic route of 115761-79-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; BIOGEN IDEC MA INC.; WO2004/92171; (2004); A2;,
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