With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57260-71-6,tert-Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,57260-71-6
To a solution of trifluoroethanol (0.32 g, 3.22 mmol) in DCM (10 mL) was added a solution of triethylamine (0.65 g, 4.82 mmol) and trifluoromethanesulfonic anhydride (1.05 g, 3.75 mmol) at 0 C and stirred at same temperature for 30 min. A solution of ieri-butyl piperazine-1- carboxylate (0.50 g, 2.68 mmol) in DCM (10 mL) was added and the reaction mixture was stirred at room temperature for 16 h. The reaction mixture was diluted with H20 (20 mL). The organic layer was separated, washed with H20 (20 mL), dried over anhydrous Na2S04 and concentrated in vacuo. The crude obtained was purified by column chromatography (silica 100- 200 mesh, 0.5 to 2% MeOH in DCM) to afford tert-butyl 4-(2,2,2-trifluoroethyl)piperazine-l- carboxylate (0.40 g, 55%) as a white solid. 1H NMR (400 MHz, DMSO- 6) delta 1.46 (s, 9H), 2.64- 2.58 (m, 4H), 2.92-3.04 (m, 2H), 3.48-3.36 (m, 4H).
The synthetic route of 57260-71-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; STOCKING, Emily, M.; HALL, Adrian; MACCOSS, Malcolm; (139 pag.)WO2017/20010; (2017); A1;,
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