1235865-77-6, 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of (7:3) acetone-methanol (3 mL), 2-((lH-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4- (4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro[l,l’-biphenyl]-2-yl)methyl)piperazin-l- yl)benzoic acid (0.5 g) and dicyclohexylamine (0.19 g) was stirred at 20-30 degree Celsius for 3-4h. The resulting slurry was filtered, washed with (7:3) acetone-methanol (2 mL) and the solid was dried under vacuum at 40-50 degree Celsius for 16 h to furnish 2-(( lH-pyrrolo[2, 3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3, 4,5,6- tetrahydro[l, l’-biphenyl]-2-yl)methyl)piperazin- l-yl)benzoic acid dicyclohexylamine salt. Yield: 60.6 % (0.4 g) HPLC Purity: 97.2 % 1H NMR (DMSO-d6): d 0.93 (s, 6H), 1.08 (m, 6H), 1.15 (m, 4H), 1.39 (t, J=6.0, 6.4 Hz, 2H), 1.50 (d, J=l2.4 Hz, 2H), 1.60 (d, J=l3.2 Hz, 4H), 1.77 (d, J=l0.8 Hz, 4H),2.l6 (m, br, 6H) 2.58 (m, 2H), 2.73 (s, 2H), 3.04 (s, 4H), 6.31 (d, J=2.8 Hz, 2H), 6.64 (d, J=7.6, Hz, 1H), 7.04 (d, J=8.0 Hz, 2H), 7.33 (d, J=8.0 Hz, 3H), 7.41 (s, 1H), 7.60 (d, J=8.8 Hz, 1H), 7.95 (d, J=2.0 Hz, 1H), 11.55 (s, 1H, NH)
1235865-77-6, As the paragraph descriping shows that 1235865-77-6 is playing an increasingly important role.
Reference：
Patent; FRESENIUS KABI ONCOLOGY LTD.; GUPTA, Chandan Kumar; DHIMAN, Navdeep; SANGHANI, Sunil; SINGH, Govind; LAHIRI, Saswata; CABRI, Walter; GUPTA, Nitin; (0 pag.)WO2020/3272; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics