With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67455-41-8,4-(Piperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.
Amine (2.5 mmol) was added to the mixture of bis-chloride (1) (0.419 g, 1 mmol) in10 mL of dry pyridine and the whole was mixed at 70 C for 12 h. The mixture was cooled down toroom temperature and the formed precipitate was filtered off and washed with ether. The raw productwas purified through recrystallization from ethanol., 67455-41-8
The synthetic route of 67455-41-8 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Zieba, Andrzej; Latocha, Ma?gorzata; Sochanik, Aleksander; Nycz, Anna; Ku?mierz, Dariusz; Molecules; vol. 21; 11; (2016);,
Piperazine – Wikipedia
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