5625-67-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.
To a mixture of rhoirhoerazin-2-one (200 mg, 2.00 mmol) and 37% aqueous HCHO (0.300 niL, 4.00 mmol) in dioxane (8 mL) and HOAc (0.100 mL) at room temperature, NaBH3CN (252 mg, 4.00 mmol) was added. After being stirred at room temperature overnight, the mixture was concentrated in vacuo. The residue was partitioned between H2O and n-BuOH. The n-BuOH phase was separated, washed with 5% NaHCO3, then concentrated in vacuo to give the 4-methyl-2-piperazinone (211 mg). MS 115.5 (M+H).
5625-67-2 Piperazin-2-one 231360, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; PORTOLA PHARMACEUTICALS, INC.; WO2006/55951; (2006); A2;,
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