With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.
55121-99-8, 2-Methanesulfmyl-7-(2-methoxy-phenyl)-pyrrolo[2, 1 -f] [ 1 ,2,4]triazine (125.0 mg, 0.0004350 mol), N,N-Diisopropylethylamine (0.114 niL, 0.000652 mol) and (4-Amino- phenyl)-(4-methyl-piperazin-l-yl)-methanone (0.191 g, 0.000870 mol) were dissolved in l-Methoxy-2-propanol (1.2 rnL, 0.013 mol) and the reaction was irradiated at 300 watts, 1800C for 40 minutes or until HPLC showed consumption of starting material. The reaction mixture was then reduced en vacuo and the product was isolated and purified by Gilson prep HPLC to afford 73.56 mg of {4-[7-(2-Methoxy-phenyl)-pyrrolo[2,l- f][l,2,4]triazin-2-ylamino]-phenyl}-(4-methyl-piperazin-l-yl)-methanone as a lyophilized powder. (M+H) = 443.8. 1H NMR (400 MHz, DMSO, d6) delta 9.74 (s, IH), 9.00 (s, IH), 7.76 (m, 3H), 7.48 (m, IH), 7.33 (d, 2H, J = 8.64 Hz), 7.23 (d, IH, J = 8.28 Hz), 7.13 (t, IH, J = 7.48 Hz), 6.97 (m, 2H), 3.81 (s, 3H), 3.06 (m, 4H), 3.26 (m, 2H), 3.07 (m, 2H), 2.83 (s, 3H).
55121-99-8 (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone 231408, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; CEPHALON, INC.; BRESLIN, Henry J.; CHATTERJEE, Sankar; DIEBOLD, James L.; DORSEY, Bruce D.; DUNN, Derek; GINGRICH, Diane E.; HOSTETLER, Greg A.; HUDKINS, Robert L.; HUNTER, Rachael; JOSEF, Kurt; LISKO, Joseph; MESAROS, Eugen F.; MILKIEWICZ, Karen L.; OTT, Gregory R.; SUNDAR, Babu G.; THEROFF, Jay P.; THIEU, Tho; TRIPATHY, Rabindranath; UNDERINER, Theodore L.; WEINBERG, Linda; WELLS, Gregory J.; ZIFICSAK, Craig A.; WO2010/71885; (2010); A1;,
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