With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3022-15-9,Piperazine-2-carboxylic acid dihydrochloride,as a common compound, the synthetic route is as follows.
Racemic 2-piperazinecarboxylic acid dihydrochloride (1) (0.78 g,6 mmol) was dissolved in aqueous sodium hydroxide (0.96 g,40 mmol) solution. Then a solution of di-tert-butyl dicarbonate (3.9 g, 17.9 mmol) in dioxane (25 mL) was added slowly. The reaction mixture was stirred overnight at room temperature. Subsequently,1 M hydrochloric acid was added to the reaction system to adjust the pH of the reaction solution to about 4. It was extracted with ethyl acetate (3 20 mL), and the organic phase was combined and dried over anhydrous sodium sulfate. The mixture was concentrated under vacuum to afford 0.88 g (2.67 mmol, 45% yield) 2 as a white solid and used directly in the next reaction. 1H NMR (500 MHz, DMSO-d6) delta 12.73 (s, 1H), 4.43 (m, 1H), 4.32 (m, 1H), 3.83(m, 1H), 3.66 (m, 1H), 3.05 (m, 2H), 2.78 (m, 1H), 1.38 (s, 18H). 13C NMR (126 MHz, DMSO-d6) delta 171.71, 171.53, 154.91, 154.68, 79.63,79.45, 79.18, 54.39, 53.07, 27.87. ESI-HRMS Calculated forC15H27N2O6 [M+H]+: 331.1869, Found: 331.1872., 3022-15-9
3022-15-9 Piperazine-2-carboxylic acid dihydrochloride 2723757, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Chen, Hongli; Huang, Rong; Jiang, Biao; Sheng, Yao; Wei, Ding; Yu, Jianghui; European Journal of Medicinal Chemistry; vol. 190; (2020);,
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