Downstream synthetic route of 132710-90-8

132710-90-8, As the paragraph descriping shows that 132710-90-8 is playing an increasingly important role.

132710-90-8, 1-Boc-4-(3-hydroxypropyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of tert-butyl 4-(3 -hydroxypropyl)piperazine- 1 -carboxylate (1.52 g, 6.2 mmol), Ph3P (2.46 g, 9.4 mmol), 12 (2.40 g, 9.4 mmol) and imidazole (1.28 g, 18.6 mmol) in DCM (100mL) was stirred at room temperature for 5 h and then diluted with DCM (200 mL). The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and evaporated. The residue was purified by chromatography (PE : EtOAc = 5 : 1) to provide tert-butyl 4-(3- iodopropyl)piperazine- 1 -carboxylate (1 .10 g, 50%) as a colorless oil.

132710-90-8, As the paragraph descriping shows that 132710-90-8 is playing an increasingly important role.

Reference:
Patent; PRINCIPIA BIOPHARMA, INC.; VERNER, Erik; BRAMELD, Kenneth Albert; WO2015/120049; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics